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Novel broad spectrum virucidal molecules against enveloped viruses

Tintori, Cristina
Civra, Andrea
Cavalli, Roberta
Tiberi, Marika
Botta, Lorenzo
Brai, Annalaura
Poli, Giulio
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Published in PLOS ONE. 2018, vol. 13, no. 12, e0208333
Abstract Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruses. For this reason, the identification of broad spectrum antiviral compounds provides a valuable opportunity for developing efficient antiviral therapies. Here we report on a class of rhodanine and thiobarbituric derivatives displaying a broad spectrum antiviral activity against seven different enveloped viruses including an HSV-2 acyclovir resistant strain with favorable selectivity indexes. Due to their selective action on enveloped viruses and to their lipid oxidation ability, we hypothesize a mechanism on the viral envelope that affects the fluidity of the lipid bilayer, thus compromising the efficiency of virus-cell fusion and preventing viral entry.
PMID: 30532192
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Research group Identification des facteurs clés impliqués dans la pathogénèse des rhinovirus et entérovirus (953)
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CAGNO, Valeria et al. Novel broad spectrum virucidal molecules against enveloped viruses. In: PLOS ONE, 2018, vol. 13, n° 12, p. e0208333. doi: 10.1371/journal.pone.0208333 https://archive-ouverte.unige.ch/unige:112685

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Deposited on : 2019-01-09

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