UNIGE document Scientific Article
previous document  unige:112685  next document
add to browser collection
Title

Novel broad spectrum virucidal molecules against enveloped viruses

Authors
Tintori, Cristina
Civra, Andrea
Cavalli, Roberta
Tiberi, Marika
Botta, Lorenzo
Brai, Annalaura
Poli, Giulio
show hidden authors show all authors [1 - 11]
Published in PLOS ONE. 2018, vol. 13, no. 12, p. e0208333
Abstract Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruses. For this reason, the identification of broad spectrum antiviral compounds provides a valuable opportunity for developing efficient antiviral therapies. Here we report on a class of rhodanine and thiobarbituric derivatives displaying a broad spectrum antiviral activity against seven different enveloped viruses including an HSV-2 acyclovir resistant strain with favorable selectivity indexes. Due to their selective action on enveloped viruses and to their lipid oxidation ability, we hypothesize a mechanism on the viral envelope that affects the fluidity of the lipid bilayer, thus compromising the efficiency of virus-cell fusion and preventing viral entry.
Identifiers
PMID: 30532192
Full text
Article (Published version) (1.5 MB) - public document Free access
Structures
Research group Identification des facteurs clés impliqués dans la pathogénèse des rhinovirus et entérovirus (953)
Citation
(ISO format)
CAGNO, Valeria et al. Novel broad spectrum virucidal molecules against enveloped viruses. In: PLOS ONE, 2018, vol. 13, n° 12, p. e0208333. https://archive-ouverte.unige.ch/unige:112685

14 hits

2 downloads

Update

Deposited on : 2019-01-09

Export document
Format :
Citation style :