Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy

Garibotto, Valentina; Wissmeyer, Michael; Giavri, Zoi; Goldstein, Rachel; Seimbille, Yann; Seeck, Margitta; Ratib, Osman; Haller, Sven; Picard, Fabienne

doi:10.1007/s00259-018-4175-0

Scientific article

Open access

English

Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy

ContributorsGaribotto, Valentina

; Wissmeyer, Michael; Giavri, Zoi; Goldstein, Rachel; Seimbille, Yann; Seeck, Margitta; Ratib, Osman; Haller, Sven; Picard, Fabienne

Published inEuropean Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 2, p. 385-395

Publication date2019

Abstract

Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [18F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.

Affiliation

Research group

Funding

Swiss National Science Foundation - PET and EEG study of the nicotinic system in epilepsy [320030_127608]

Citation (ISO format)

GARIBOTTO, Valentina et al. Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy. In: European Journal of Nuclear Medicine and Molecular Imaging, 2019, vol. 46, n° 2, p. 385–395. doi: 10.1007/s00259-018-4175-0

Article (Published version)

Article (Accepted version)

Identifiers

PID : unige:112562
DOI : 10.1007/s00259-018-4175-0
PMID : 30269157

ISSN of the journal1619-7070

520views

319downloads

Creation11/15/2018 5:33:00 PM

First validation11/15/2018 5:33:00 PM

Update time03/15/2023 3:19:43 PM

Status update03/15/2023 3:19:42 PM

Last indexation08/30/2023 7:44:49 PM

Archive ouverte UNIGE

Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy

Technical informations