Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy

Garibotto, Valentina; Wissmeyer, Michael; Giavri, Zoi; Goldstein, Rachel; Seimbille, Yann; Seeck, Margitta; Ratib, Osman; Haller, Sven; Picard, Fabienne

doi:10.1007/s00259-018-4175-0

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Title		Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy
Authors		Garibotto, Valentina Wissmeyer, Michael Giavri, Zoi Goldstein, Rachel Seimbille, Yann Seeck, Margitta Ratib, Osman Haller, Sven Picard, Fabienne show all authors [1 - 9]
Published in		European Journal of Nuclear Medicine and Molecular Imaging. 2019, vol. 46, no. 2, p. 385-395
Abstract		Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [18F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.
Identifiers		DOI: 10.1007/s00259-018-4175-0 PMID: 30269157
Full text		Article (Published version) (1 MB) - Limited access to UNIGE Article (Author postprint) (1.1 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Epilepsie et Chirurgie (149) Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
Project		FNS: 320030_127608
Citation (ISO format)		GARIBOTTO, Valentina et al. Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy. In: European Journal of Nuclear Medicine and Molecular Imaging, 2019, vol. 46, n° 2, p. 385-395. https://archive-ouverte.unige.ch/unige:112562