This paper presents a study of the production of a single W boson in association with one or more jets in proton-antiproton collisions at s=1.96 TeV, using the entire data set collected in 2001–2011 by the Collider Detector at Fermilab at the Tevatron, which corresponds to an integrated luminosity of 9.0 fb−1. The W boson is identified through its leptonic decays into electron and muon. The production cross sections are measured for each leptonic decay mode and combined after testing that the ratio of the W(→μν)+jets cross section to the W(→eν)+jets cross section agrees with the hypothesis of e-μ lepton universality. The combination of measured cross sections, differential in the inclusive jet multiplicity (W+≥N jets with N=1, 2, 3, or 4) and in the transverse energy of the leading jet, are compared with theoretical predictions.