In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T

Daire, Jean-Luc; Hyacinthe, Jean-Noël; Tatar, I.; Montet-Abou, Karin; Ivancevic, M K.; Masterson, Karen; Jorge-Costa, Manuel; Morel, Denis; Vallée, Jean-Paul

doi:10.1002/mrm.21493

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Title		In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T
Authors		Daire, Jean-Luc Hyacinthe, Jean-Noël Tatar, I. Montet-Abou, Karin Ivancevic, M K. Masterson, Karen Jorge-Costa, Manuel Morel, Denis Vallée, Jean-Paul show all authors [1 - 9]
Published in		Magnetic Resonance in Medicine. 2008, vol. 59, no. 6, p. 1422-1430
Abstract		The aim of this study was to measure the myocardial area at risk in rat, using MRI and manganese injection during a coronary occlusion/reperfusion model at 1.5T. A sequential protocol with occlusion and MnCl2 injection immediately followed by MRI was used with the assumption that MnCl2-induced contrast persistence is enough to accurately image the area at risk 90 min after occlusion. A total of 15 adult rats underwent a single 30-min episode of coronary occlusion followed by reperfusion. MnCl2 was injected (25 micromol/kg) at the beginning of the occlusion for 11 rats (group 1) and 6 h after reperfusion for four animals (group 2). A deficit of signal enhancement was observed in all rats. Hypoenhancement area in group 1 was correlated to the area at risk delineated by methylene blue (r=0.96, P<0.0001) whereas in group 2 it was correlated to the infarct area given by triphenyltetrazolium chloride (TTC) solution (r=0.98, P=0.003). The area at risk size was significantly correlated with left ventricle ejection fraction (LVEF), end-systolic volume and anterolateral wall thickening. This work demonstrates that hypoenhanced zone obtained after manganese injection during occlusion represents the area at risk and not only the infarct zone.
Keywords		Analysis of Variance — Animals — Chlorides/diagnostic use — Contrast Media — Disease Models, Animal — Electrocardiography — Image Enhancement/methods — Image Processing, Computer-Assisted/methods — Magnetic Resonance Imaging/methods — Manganese Compounds/diagnostic use — Myocardial Infarction/pathology — Rats — Rats, Sprague-Dawley — Risk Assessment
Identifiers		DOI: 10.1002/mrm.21493 PMID: 18506788
Full text		Article (Accepted version) (523 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Research group		Imagerie cardiaque fonctionnelle (541)
Citation (ISO format)		DAIRE, Jean-Luc et al. In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T. In: Magnetic Resonance in Medicine, 2008, vol. 59, n° 6, p. 1422-1430. doi: 10.1002/mrm.21493 https://archive-ouverte.unige.ch/unige:1125