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In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T |
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Published in | Magnetic resonance in medicine. 2008, vol. 59, no. 6, p. 1422-1430 | |
Abstract | The aim of this study was to measure the myocardial area at risk in rat, using MRI and manganese injection during a coronary occlusion/reperfusion model at 1.5T. A sequential protocol with occlusion and MnCl2 injection immediately followed by MRI was used with the assumption that MnCl2-induced contrast persistence is enough to accurately image the area at risk 90 min after occlusion. A total of 15 adult rats underwent a single 30-min episode of coronary occlusion followed by reperfusion. MnCl2 was injected (25 micromol/kg) at the beginning of the occlusion for 11 rats (group 1) and 6 h after reperfusion for four animals (group 2). A deficit of signal enhancement was observed in all rats. Hypoenhancement area in group 1 was correlated to the area at risk delineated by methylene blue (r=0.96, P<0.0001) whereas in group 2 it was correlated to the infarct area given by triphenyltetrazolium chloride (TTC) solution (r=0.98, P=0.003). The area at risk size was significantly correlated with left ventricle ejection fraction (LVEF), end-systolic volume and anterolateral wall thickening. This work demonstrates that hypoenhanced zone obtained after manganese injection during occlusion represents the area at risk and not only the infarct zone. | |
Keywords | Analysis of Variance — Animals — Chlorides/diagnostic use — Contrast Media — Disease Models, Animal — Electrocardiography — Image Enhancement/methods — Image Processing, Computer-Assisted/methods — Magnetic Resonance Imaging/methods — Manganese Compounds/diagnostic use — Myocardial Infarction/pathology — Rats — Rats, Sprague-Dawley — Risk Assessment | |
Identifiers | DOI: 10.1002/mrm.21493 PMID: 18506788 | |
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Research group | Imagerie cardiaque fonctionnelle (541) | |
Citation (ISO format) | DAIRE, Jean-Luc et al. In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T. In: Magnetic resonance in medicine, 2008, vol. 59, n° 6, p. 1422-1430. doi: 10.1002/mrm.21493 https://archive-ouverte.unige.ch/unige:1125 |