UNIGE document Scientific Article
previous document  unige:112495  next document
add to browser collection
Title

The Role of NK Cells in Pig-to-Human Xenotransplantation

Authors
Schneider, Mårten K J
Published in Journal of Immunology Research. 2017, vol. 2017, p. 4627384
Abstract Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify targets for therapeutic interventions. Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors. The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed. Finally, we present the status of phenotypic and functional characterization of nonhuman primate (NHP) NK cells, essential for studying their role in xenograft rejection using preclinical pig-to-NHP models, and summarize key advances and important perspectives for future research.
Keywords AnimalsAnimalsGenetically ModifiedCell AdhesionCell LineCytotoxicityImmunologicDendritic Cells/immunology/transplantationEndothelial Cells/immunologyGenetic TherapyGraft Rejection/immunology/prevention & controlHLA Antigens/geneticsHeterografts/immunologyHumansImmunotherapyAdoptive/methodsKiller CellsNatural/immunologyPrimatesSwineT-LymphocytesRegulatory/immunology/transplantationTransplantationHeterologous
Identifiers
PMID: 29410970
Full text
Article (Published version) (17.8 MB) - public document Free access
Structures
Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
Citation
(ISO format)
PUGA YUNG, Gisella, SCHNEIDER, Mårten K J, SEEBACH, Jorg Dieter. The Role of NK Cells in Pig-to-Human Xenotransplantation. In: Journal of Immunology Research, 2017, vol. 2017, p. 4627384. https://archive-ouverte.unige.ch/unige:112495

21 hits

6 downloads

Update

Deposited on : 2018-12-20

Export document
Format :
Citation style :