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Scientific article
English

Multimodal treatment of craniofacial osteosarcoma with high-grade histology. A single-center experience over 35 years

Published inNeurosurgical Review, vol. 40, no. 3, p. 449-460
Publication date2017
Abstract

High-grade craniofacial osteosarcoma (CFOS) is an aggressive malignancy with a poor prognosis. Our goals were to evaluate treatment outcomes in those treated at a single referral institution over 35 years and to compare our results to the available literature. A retrospective analysis of all 42 patients treated between 1980 and 2015 at Oslo University Hospital, Norway, identified in a prospectively collected database, was conducted. Mean follow-up was 79.6 months. Overall survival at 2 and 5 years was 70.5 and 44.7%, respectively. The corresponding disease-specific survival rates were 73.0 and 49.8%. Treatment was surgery only in eight cases. Additional therapy was administered in 34 patients: chemotherapy in nine, radiotherapy in seven, and a combination of these in 18 cases. Stratified analysis by resection margins demonstrated significantly better survival at 2 and 5 years after radical surgical treatment. Neoadjuvant chemotherapy and subsequent adequate surgery resulted in better survival than surgery alone. Half of the patients either had a primary or familial cancer predisposition. This is the largest single-center study conducted on high-grade CFOS to date. Our experience indicates that neoadjuvant chemotherapy with complete surgical resection significantly improved survival, compared to surgery alone.

Keywords
  • Adolescent
  • Adult
  • Aged
  • 80 and over
  • Child
  • Combined Modality Therapy
  • Facial Neoplasms/surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoadjuvant Therapy
  • Neurosurgical Procedures
  • Osteosarcoma/surgery/therapy
  • Radiotherapy/methods
  • Retrospective Studies
  • Skull Neoplasms/surgery
  • Survival Analysis
  • Treatment Outcome
  • Young Adult
Citation (ISO format)
KÖNIG, Marton et al. Multimodal treatment of craniofacial osteosarcoma with high-grade histology. A single-center experience over 35 years. In: Neurosurgical Review, 2017, vol. 40, n° 3, p. 449–460. doi: 10.1007/s10143-016-0802-z
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ISSN of the journal0344-5607
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