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Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius

Péresse, Tiphaine
Jézéquel, Gwenaëlle
Pham, Van-Cuong
Huong, Doan T M
Blanchard, Florent
Bignon, Jérôme
Lévaique, Hélène
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Published in Journal of Natural Products. 2017, vol. 80, no. 10, p. 2684-2691
Abstract With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated stilbenes, schweinfurthins K-Q (7-13), were isolated, along with vedelianin (1), schwenfurthins E-G (2-4), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 1-13 were evaluated against the human glioblastoma (U87) and lung (A549) cancer cell lines.
Keywords Antineoplastic AgentsPhytogenic/chemistry/isolation & purification/pharmacologyDrug Screening AssaysAntitumorEuphorbiaceae/chemistryFlavonoids/chemistryFruit/chemistryHumansMolecular StructureNuclear Magnetic ResonanceBiomolecularPlant Leaves/chemistryPrenylationStilbenes/chemistry/isolation & purification/pharmacologyVietnam
PMID: 28972755
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Research group Phytochimie et produits naturels bioactifs
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PÉRESSE, Tiphaine et al. Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius. In: Journal of Natural Products, 2017, vol. 80, n° 10, p. 2684-2691. doi: 10.1021/acs.jnatprod.7b00409 https://archive-ouverte.unige.ch/unige:112403

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Deposited on : 2018-12-18

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