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Title

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial

Authors
Cahn, Pedro
Kaplan, Richard
Sax, Paul E
Squires, Kathleen
Molina, Jean-Michel
Avihingsanon, Anchalee
Ratanasuwan, Winai
Rojas, Evelyn
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Published in The Lancet HIV. 2017, vol. 4, no. 11, p. e486-e494
Abstract Once daily regimens are preferred for HIV-1 treatment, to facilitate adherence and improve quality of life. We compared a new once daily formulation of raltegravir to the currently marketed twice daily formulation.
Keywords AdministrationOralAdultAnti-HIV Agents/administration & dosage/adverse effects/therapeutic useBiological AvailabilityCoinfection/virologyDouble-Blind MethodEmtricitabine/administration & dosage/adverse effects/pharmacokinetics/therapeutic useFemaleHIV Infections/drug therapy/virologyHIV-1/drug effects/physiologyHepatitis B/virologyHepatitis C/virologyHumansMaleQuality of LifeRNAViral/blood/drug effectsRaltegravir Potassium/administration & dosage/adverse effects/pharmacokinetics/therapeutic useTenofovir/administration & dosage/adverse effects/pharmacokinetics/therapeutic useViral Load/drug effects
Identifiers
PMID: 28918877
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Research group VIH/SIDA (930)
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CAHN, Pedro et al. Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial. In: The Lancet HIV, 2017, vol. 4, n° 11, p. e486-e494. doi: 10.1016/S2352-3018(17)30128-5 https://archive-ouverte.unige.ch/unige:112380

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Deposited on : 2018-12-18

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