en
Scientific article
English

Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis

Published inThe Lancet HIV, vol. 4, no. 10, p. e433-e441
Publication date2017
Abstract

Selection of optimal second-line antiretroviral therapy (ART) has important clinical and programmatic implications. To inform the 2016 revision of the WHO ART guidelines, we assessed the comparative effectiveness and safety of available second-line ART regimens for adults and adolescents in whom first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens have failed.

Keywords
  • Acquired Immunodeficiency Syndrome/drug therapy
  • Adolescent
  • Adult
  • Anti-HIV Agents/administration & dosage/adverse effects/therapeutic use
  • Female
  • HIV Infections/drug therapy
  • HIV Protease Inhibitors/administration & dosage/adverse effects/therapeutic use
  • HIV-1/drug effects
  • Humans
  • Lopinavir/administration & dosage/adverse effects/therapeutic use
  • Male
  • Network Meta-Analysis
  • Prospective Studies
  • Raltegravir Potassium/administration & dosage/adverse effects/therapeutic use
  • Retrospective Studies
  • Reverse Transcriptase Inhibitors/administration & dosage/adverse effects/therapeutic use
  • Ritonavir/administration & dosage/adverse effects/therapeutic use
Research group
Citation (ISO format)
KANTERS, Steve et al. Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis. In: The Lancet HIV, 2017, vol. 4, n° 10, p. e433–e441. doi: 10.1016/S2352-3018(17)30109-1
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Article (Published version)
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Identifiers
ISSN of the journal2352-3018
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