Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis

Kanters, Steve; Socias, Maria Eugenia; Paton, Nicholas I; Vitoria, Marco; Doherty, Meg; Ayers, Dieter; Popoff, Evan; Chan, Keith; Cooper, David A; Wiens, Matthew O; Calmy, Alexandra; Ford, Nathan; Nsanzimana, Sabin; Mills, Edward J

doi:10.1016/S2352-3018(17)30109-1

Scientific article

English

Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis

ContributorsKanters, Steve; Socias, Maria Eugenia; Paton, Nicholas I; Vitoria, Marco; Doherty, Meg; Ayers, Dieter; Popoff, Evan; Chan, Keith; Cooper, David A; Wiens, Matthew O; Calmy, Alexandra

; Ford, Nathan; Nsanzimana, Sabin; Mills, Edward J

Published inThe Lancet HIV, vol. 4, no. 10, p. e433-e441

Publication date2017

Abstract

Selection of optimal second-line antiretroviral therapy (ART) has important clinical and programmatic implications. To inform the 2016 revision of the WHO ART guidelines, we assessed the comparative effectiveness and safety of available second-line ART regimens for adults and adolescents in whom first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens have failed.

Keywords

Acquired Immunodeficiency Syndrome/drug therapy
Adolescent
Adult
Anti-HIV Agents/administration & dosage/adverse effects/therapeutic use
Female
HIV Infections/drug therapy
HIV Protease Inhibitors/administration & dosage/adverse effects/therapeutic use
HIV-1/drug effects
Humans
Lopinavir/administration & dosage/adverse effects/therapeutic use
Male
Network Meta-Analysis
Prospective Studies
Raltegravir Potassium/administration & dosage/adverse effects/therapeutic use
Retrospective Studies
Reverse Transcriptase Inhibitors/administration & dosage/adverse effects/therapeutic use
Ritonavir/administration & dosage/adverse effects/therapeutic use

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

VIH/SIDA (930)

Citation (ISO format)

KANTERS, Steve et al. Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis. In: The Lancet HIV, 2017, vol. 4, n° 10, p. e433–e441. doi: 10.1016/S2352-3018(17)30109-1

Article (Published version)

Identifiers

PID : unige:112379
DOI : 10.1016/S2352-3018(17)30109-1
PMID : 28784426

Journal ISSN2352-3018

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Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis

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