Scientific article
English

Boosted protease inhibitor monotherapy versus boosted protease inhibitor plus lamivudine dual therapy as second-line maintenance treatment for HIV-1-infected patients in sub-Saharan Africa (ANRS12 286/MOBIDIP)

Published inThe Lancet HIV, vol. 4, no. 9, p. e384-e392
Publication date2017
Abstract

Despite satisfactory efficacy of WHO-recommended second-line antiretroviral treatment for patients with HIV in low-income countries, the need for simplified, low-cost, and less-toxic maintenance strategies remains high. We compared boosted protease inhibitor monotherapy with dual therapy with boosted protease inhibitor plus lamivudine in patients on second-line antiretrovial therapy (ART).

Keywords
  • Adult
  • Africa South of the Sahara/epidemiology
  • Anti-HIV Agents/administration & dosage/economics/therapeutic use
  • Antiretroviral Therapy
  • Highly Active/methods
  • CD4 Lymphocyte Count
  • Cameroon/epidemiology
  • Drug Therapy
  • Combination/methods
  • Female
  • HIV Infections/drug therapy/epidemiology/virology
  • HIV Protease Inhibitors/administration & dosage/therapeutic use
  • HIV-1
  • Humans
  • Lamivudine/administration & dosage/therapeutic use
  • Male
  • Middle Aged
  • Reverse Transcriptase Inhibitors/administration & dosage/therapeutic use
  • Senegal/epidemiology
  • Viral Load/drug effects
NoteSous-titre : a multicentre, randomised, parallel, open-label, superiority trial.
Research groups
Citation (ISO format)
CIAFFI, Laura et al. Boosted protease inhibitor monotherapy versus boosted protease inhibitor plus lamivudine dual therapy as second-line maintenance treatment for HIV-1-infected patients in sub-Saharan Africa (ANRS12 286/MOBIDIP). In: The Lancet HIV, 2017, vol. 4, n° 9, p. e384–e392. doi: 10.1016/S2352-3018(17)30069-3
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN2352-3018
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