Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study

Beguelin, Charles; Friolet, Nicole; Moradpour, Darius; Sahli, Roland; Suter-Riniker, Franziska; Lüthi, Alexander; Cavassini, Matthias; Günthard, Huldrych F; Battegay, Manuel; Bernasconi, Enos; Schmid, Patrick; Calmy, Alexandra; Atkinson, Andrew; Rauch, Andri; Wandeler, Gilles

doi:10.1093/cid/cix125

Scientific article

English

Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study

ContributorsBeguelin, Charles; Friolet, Nicole; Moradpour, Darius; Sahli, Roland; Suter-Riniker, Franziska; Lüthi, Alexander; Cavassini, Matthias; Günthard, Huldrych F; Battegay, Manuel; Bernasconi, Enos; Schmid, Patrick; Calmy, Alexandra

; Atkinson, Andrew; Rauch, Andri; Wandeler, Gilles

Published inClinical Infectious Diseases, vol. 64, no. 9, p. 1275-1278

Publication date2017

Abstract

We analyzed changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during tenofovir-containing antiretroviral therapy among patients with a replicating HDV infection in the Swiss HIV Cohort Study. Only 28.6% experienced a ≥2.0 log reduction in HDV RNA, and 14.3% had undetectable HDV VL within 5 years.

Keywords

Adult
Anti-HIV Agents/therapeutic use
Cohort Studies
Female
HIV Infections/complications/drug therapy
Hepatitis B virus/isolation & purification
Hepatitis B
Chronic/complications/virology
Hepatitis D/virology
Hepatitis Delta Virus/drug effects/isolation & purification/physiology
Humans
Male
Middle Aged
Switzerland
Tenofovir/therapeutic use
Viral Load
Virus Replication/drug effects

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

VIH/SIDA (930)

Citation (ISO format)

BEGUELIN, Charles et al. Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study. In: Clinical Infectious Diseases, 2017, vol. 64, n° 9, p. 1275–1278. doi: 10.1093/cid/cix125

Article (Published version)

Identifiers

PID : unige:112373
DOI : 10.1093/cid/cix125
PMID : 28199492

Journal ISSN1058-4838

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Impact of Tenofovir on Hepatitis Delta Virus Replication in the Swiss Human Immunodeficiency Virus Cohort Study

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