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The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women

Harrington, Laura B
Cushman, Mary
Kaunitz, Andrew M
Rossouw, Jacques E
Allison, Matthew A
Martin, Lisa W
Johnson, Karen C
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Published in Menopause. 2017, vol. 24, no. 4, p. 360-370
Abstract OBJECTIVE: Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women's Health Initiative (WHI) Hormone Therapy trial postmenopausal participants. METHODS: This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS presence and severity reported in the 4 weeks before WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio, and thrombin generation. Using multiple linear regression, we estimated the adjusted average difference in each hemostatic parameter associated with VMS presence and severity. A multiple comparisons-corrected P value was computed using the P-min procedure to determine statistical significance of our smallest observed P value. RESULTS: Women were 67 years of age on average and 33% reported VMS presence at baseline. There was some suggestion that VMS presence may be associated with a -0.34 adjusted difference in normalized activated protein C sensitivity ratio compared with no VMS (95% CI, -0.60 to -0.087; P = 0.009), but this association was not significant after correction for multiple comparisons (P = 0.073). VMS presence or severity was not significantly associated with the other hemostatic parameters. CONCLUSIONS: We found no convincing evidence that VMS presence or severity was associated with levels of hemostatic parameters among postmenopausal women.
Keywords AgedAntigens/bloodAntithrombin Proteins/metabolismCross-Sectional StudiesFemaleFibrin Fibrinogen Degradation Products/metabolismHemostasisHot Flashes/bloodHumansLipoproteins/bloodMiddle AgedPlasminogen Activator Inhibitor 1/bloodPostmenopause/bloodProtein C/immunologyProtein S/immunologySeverity of Illness IndexSweatingSymptom AssessmentThrombin/biosynthesis
PMID: 27922933
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Research group La maladie thromboembolique veineuse (808)
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HARRINGTON, Laura B et al. The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women. In: Menopause, 2017, vol. 24, n° 4, p. 360-370. doi: 10.1097/GME.0000000000000777 https://archive-ouverte.unige.ch/unige:112328

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Deposited on : 2018-12-14

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