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Clinical validity of presynaptic dopaminergic imaging with 123I-ioflupane and noradrenergic imaging with 123I-MIBG

Sonni, Ida
Ratib, Osman
Picco, Agnese
Herholz, Karl
Nobili, Flavio
Varrone, Andrea
Published in Neurobiology of Aging. 2017, vol. 52, p. 228-242
Abstract The use of biomarkers (BMs) for accurate diagnosis of Alzheimer's disease (AD) has been proposed by recent diagnostic criteria; however, their maturity is not sufficient to grant implementation in the clinical routine. A proper diagnostic process requires not only confirmation of the disease but also the exclusion of similar disorders entering differential diagnosis, like dementia with Lewy bodies (DLB). This review is aimed at evaluating the clinical validity of 123I-ioflupane brain single photon emission tomography and 123I-MIBG cardiac scintigraphy as imaging BMs for DLB. For this purpose, we used an adapted version of the 5-phase oncology framework for BMs development. A review of the literature was conducted using homogenous search criteria with other BMs addressed in parallel reviews. Results of our literature search showed that the rationale for the use of both BMs in the differential diagnosis of DLB and AD is strong (phase 1) and that they allow a good discrimination ability (phase 2), but studies investigating BMs distribution antemortem and postmortem on pathology are lacking. Moreover, thresholds for test positivity have not been defined for 123I-MIBG. The 2 BMs have not been yet assessed in early phases of DLB and AD (phase 3). No phase 4 and phase 5 studies have so far been carried out. This review highlights the priorities to address in future investigations to enable the proper use of 123I-ioflupane and 123I-MIBG for the differential diagnosis of dementia.
Keywords 3-IodobenzylguanidineAlzheimer Disease/diagnostic imagingBiomarkersCognitive Dysfunction/diagnostic imagingDiagnosisDifferentialHeart/diagnostic imagingHumansIodine RadioisotopesLewy Body Disease/diagnostic imagingNortropanesRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsTomographyEmission-ComputedSingle-Photon
PMID: 28317651
Note Clinical validity of presynaptic dopaminergic imaging with 123I-ioflupane and noradrenergic imaging with 123I-MIBG in the differential diagnosis between Alzheimer's disease and dementia with Lewy bodies in the context of a structured 5-phase development framework.
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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SONNI, Ida et al. Clinical validity of presynaptic dopaminergic imaging with 123I-ioflupane and noradrenergic imaging with 123I-MIBG. In: Neurobiology of Aging, 2017, vol. 52, p. 228-242. doi: 10.1016/j.neurobiolaging.2016.04.026 https://archive-ouverte.unige.ch/unige:112287

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Deposited on : 2018-12-14

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