UNIGE document Professional Article
previous document  unige:112281  next document
add to browser collection
Title

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Authors
Sanchez-Mut, Jose V.
Krishna-K, K.
show hidden authors show all authors [1 - 12]
Published in Nature Communications. 2017, vol. 8, no. 1
Abstract Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the periphery act to control dendritic maturation is unclear. Here, using genetic and surgical manipulations of sensory input in mouse somatosensory thalamocortical neurons, we show that membrane excitability is a critical component of dendritic development. Using a combination of genetic approaches, we find that ablation of N-methyl-D-aspartate (NMDA) receptors during postnatal development leads to epigenetic repression of Kv1.1-type potassium channels, increased excitability, and impaired dendritic maturation. Lesions to whisker input pathways had similar effects. Overexpression of Kv1.1 was sufficient to enable dendritic maturation in the absence of sensory input. Thus, Kv1.1 acts to tune neuronal excitability and maintain it within a physiological range, allowing dendritic maturation to proceed. Together, these results reveal an input-dependent control over neuronal excitability and dendritic complexity in the development and plasticity of sensory pathways.
Identifiers
Full text
Structures
Research group Neurobiologie développementale et plasticité (880)
Project Prof
Citation
(ISO format)
FRANGEUL, Laura et al. Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons. In: Nature Communications, 2017, vol. 8, n° 1. https://archive-ouverte.unige.ch/unige:112281

51 hits

16 downloads

Update

Deposited on : 2018-12-14

Export document
Format :
Citation style :