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Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest - A TTM-Trial Substudy

Publié dansPLOS ONE, vol. 12, no. 1, e0168894
Date de publication2017
Résumé

Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population.

Mots-clés
  • Biomarkers/blood
  • Humans
  • Hypothermia, Induced
  • Out-of-Hospital Cardiac Arrest/mortality/pathology
  • Phosphopyruvate Hydratase/blood
  • Prospective Studies
  • Rewarming
  • Treatment Outcome
  • Unconsciousness/pathology
Citation (format ISO)
WIBERG, Sebastian et al. Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest - A TTM-Trial Substudy. In: PLOS ONE, 2017, vol. 12, n° 1, p. e0168894. doi: 10.1371/journal.pone.0168894
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Article (Published version)
Identifiants
ISSN du journal1932-6203
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Informations techniques

Création15/10/2018 11:15:00
Première validation15/10/2018 11:15:00
Heure de mise à jour15/03/2023 15:15:05
Changement de statut15/03/2023 15:15:03
Dernière indexation12/02/2024 11:37:04
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