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Doctoral thesis
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English

Effects of physiological overexpression of SIRT6 in metabolism and cancer

Contributors

Maciel Ioris, Rafael

Directors

Coppari, Roberto; Loewith, Robbie Joséph

Defense date

2018-11-20

Abstract

Sirtuins are a family of conserved enzymes which have in common a deacetylase domain and a dependency for NAD+ as co-substrate. The silent information regulator 2 (Sir2) from yeast Saccharomyces cerevisiae, when overexpressed resulted in lifespan extension. Several mammalian Sirtuin family members are able to improve healthspan however, only SIRT6 was proved able to extent lifespan. The mechanisms behind life span extension is unclear but hypothesized to be due to SIRT6 capacity to maintain genomic stability, improve insulin signalling and reduce tumorigenesis. In order to address these issues we used a mouse model were SIRT6 is physiologically overexpressed. Our data indicate that SIRT6 improve insulin sensitivity in skeletal muscle and liver protecting against diet-induced T2DM and, in the cancer context, SIRT6 suppresses cancer stem cells diminishing in vitro and in vivo tumorigenesis.

UNIGE affiliation entities

UNIGE research groups

Funding

  • Autre - Ciencia sem Fronteiras - CAPES - Brazil

Citation (ISO format)

MACIEL IORIS, Rafael. Effects of physiological overexpression of SIRT6 in metabolism and cancer. Doctoral Thesis, 2018. doi: 10.13097/archive-ouverte/unige:112205

Main files (1)

Thesis

Identifiers

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Technical informations

Creation

27/11/2018 14:10:00

First validation

27/11/2018 14:10:00

Update

15/03/2023 15:14:03

Status update

15/03/2023 15:14:02

Last indexation

29/09/2025 10:36:15
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