en
Scientific article
English

TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity

Published inJournal of neuroimmunology, vol. 133, no. 1-2, p. 116-123
Publication date2002
Abstract

TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation.

Keywords
  • Animals
  • Apoptosis Regulatory Proteins
  • Astrocytes/immunology/ metabolism
  • Carrier Proteins/ genetics/pharmacology
  • Cell Division/drug effects/genetics/immunology
  • Cells, Cultured
  • Central Nervous System/growth & development/immunology/ metabolism
  • Disease Progression
  • Disease Susceptibility/immunology
  • Encephalomyelitis, Autoimmune, Experimental/genetics/immunology/ metabolism
  • Gene Expression Regulation/immunology
  • Inflammation Mediators/ pharmacology
  • Mice
  • Mice, Transgenic
  • Microglia/immunology/ metabolism
  • RNA, Messenger/immunology/metabolism
  • Tumor Necrosis Factors
Affiliation Not a UNIGE publication
Citation (ISO format)
DESPLAT-JEGO, Sophie et al. TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity. In: Journal of neuroimmunology, 2002, vol. 133, n° 1-2, p. 116–123. doi: 10.1016/s0165-5728(02)00368-5
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ISSN of the journal0165-5728
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