TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity

Desplat-Jego, Sophie; Varriale, Simone; Creidy, Rita; Terra, Rafik; Bernard, Dominique; Khrestchatisky, Michel; Izui, Shozo; Chicheportiche, Yves; Boucraut, Jose

doi:10.1016/s0165-5728(02)00368-5

Scientific article

English

TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity

ContributorsDesplat-Jego, Sophie; Varriale, Simone; Creidy, Rita; Terra, Rafik; Bernard, Dominique; Khrestchatisky, Michel; Izui, Shozo; Chicheportiche, Yves; Boucraut, Jose

Published inJournal of neuroimmunology, vol. 133, no. 1-2, p. 116-123

Publication date2002

Abstract

TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation.

Keywords

Animals
Apoptosis Regulatory Proteins
Astrocytes/immunology/ metabolism
Carrier Proteins/ genetics/pharmacology
Cell Division/drug effects/genetics/immunology
Cells, Cultured
Central Nervous System/growth & development/immunology/ metabolism
Disease Progression
Disease Susceptibility/immunology
Encephalomyelitis, Autoimmune, Experimental/genetics/immunology/ metabolism
Gene Expression Regulation/immunology
Inflammation Mediators/ pharmacology
Mice
Mice, Transgenic
Microglia/immunology/ metabolism
RNA, Messenger/immunology/metabolism
Tumor Necrosis Factors

Affiliation Not a UNIGE publication

Citation (ISO format)

DESPLAT-JEGO, Sophie et al. TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity. In: Journal of neuroimmunology, 2002, vol. 133, n° 1-2, p. 116–123. doi: 10.1016/s0165-5728(02)00368-5

Article

Identifiers

PID : unige:11220
DOI : 10.1016/s0165-5728(02)00368-5
PMID : 12446014

Commercial URLhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T03-477F622-6-F&_cdi=4851&_user=779890&_pii=S0165572802003685&_orig=search&_coverDate=12%2F31%2F2002&_sk=998669998&view=c&wchp=dGLzVzb-zSkWA&md5=18eb38170cff7661973648a34474867a&ie=/sdarticle.pdf

ISSN of the journal0165-5728

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TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity

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