

![]() |
Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women |
|
Authors | ||
Published in | European Eating Disorders Review. 2017, vol. 25, no. 1, p. 19-25 | |
Abstract | This study aimed to investigate associations between oxytocin receptor gene (OXT-R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample. We studied 3698 women from the Avon Longitudinal Study of Parents and Children (ALSPAC) who participated in a two-phase prevalence study of lifetime ED and had genotype data. The GG rs53576 genotype was associated with binge eating and purging, and the rs2254298 AG/AA genotype with restrictive eating lifetime. In addition, the rs2254298 AG/AA genotype interacted with poor maternal care to increase the odds of binge eating and purging (odds ratio = 4.40 (95% confidence intervals: 1.11-17.4)). This study replicates previous findings of an association between OXT-R polymorphisms and ED, and it is the first to show an interaction between OXT-R genotype and poor maternal care. As such, these findings highlight the important role of oxytocin in understanding the pathophysiology of ED. © 2016 The Authors European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. | |
Keywords | Adult — Child — Feeding and Eating Disorders/genetics/psychology — Female — Genetic Predisposition to Disease — Genotype — Humans — Longitudinal Studies — Maternal Behavior — Polymorphism, Genetic — Receptors, Oxytocin/genetics — United Kingdom | |
Identifiers | DOI: 10.1002/erv.2486 PMID: 27862641 | |
Full text | ||
Research group | Troubles de l'alimentation, des comportements alimentaires et autres troubles associés (996) | |
Citation (ISO format) | MICALI, Nadia et al. Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women. In: European Eating Disorders Review, 2017, vol. 25, n° 1, p. 19-25. doi: 10.1002/erv.2486 https://archive-ouverte.unige.ch/unige:112189 |