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Title

Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women
Authors
Micali, Nadia
Crous-Bou, Marta
Treasure, Janet
Lawson, Elizabeth A
Published in European Eating Disorders Review. 2017, vol. 25, no. 1, p. 19-25
Abstract This study aimed to investigate associations between oxytocin receptor gene (OXT-R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample. We studied 3698 women from the Avon Longitudinal Study of Parents and Children (ALSPAC) who participated in a two-phase prevalence study of lifetime ED and had genotype data. The GG rs53576 genotype was associated with binge eating and purging, and the rs2254298 AG/AA genotype with restrictive eating lifetime. In addition, the rs2254298 AG/AA genotype interacted with poor maternal care to increase the odds of binge eating and purging (odds ratio = 4.40 (95% confidence intervals: 1.11-17.4)). This study replicates previous findings of an association between OXT-R polymorphisms and ED, and it is the first to show an interaction between OXT-R genotype and poor maternal care. As such, these findings highlight the important role of oxytocin in understanding the pathophysiology of ED. © 2016 The Authors European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd.
Keywords Adult — Child — Feeding and Eating Disorders/genetics/psychology — Female — Genetic Predisposition to Disease — Genotype — Humans — Longitudinal Studies — Maternal Behavior — Polymorphism, Genetic — Receptors, Oxytocin/genetics — United Kingdom
Identifiers
PMID: 27862641
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Article (Published version) (137 Kb) - public document Free access
Research group Troubles de l'alimentation, des comportements alimentaires et autres troubles associés (996)
Citation
(ISO format) 		MICALI, Nadia et al. Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women. In: European Eating Disorders Review, 2017, vol. 25, n° 1, p. 19-25. doi: 10.1002/erv.2486 https://archive-ouverte.unige.ch/unige:112189

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Deposited on : 2018-12-10

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