For more than 30 years, the remarkable superconducting properties of REBa2Cu3O7−x (RE = rare earth) compounds have triggered research studies across the world. Accordingly, significant progresses have been made both from a basic understanding and a fabrication processes perspective. Yet, today, the major technological bottleneck towards the spread of their practical uses remains the exponential decay of their critical current with grain misorientation in polycrystalline samples. In this work, we used an ionic liquid to apply extremely high transverse electric fields to YBa2Cu3O7−x thin films containing a single well-defined low-angle grain boundary. Our study shows that this technique is very effective to tune the IV characteristics of these weak-links. In-magnetic field measurements allow us to discuss the type of the vortices present at the grain boundary and to unveil a large variation of the local depairing current density with gating. Comparing our results with the ones obtained on chemically-doped grain boundaries, we discuss routes to evaluate the role of local strain in the loss of transparency at cuprates low-angle grain boundaries. In short, this study offers a new opportunity to discuss scenarios leading to the reduced transport capabilities of grain boundaries in cuprates.