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Hepatitis C virus transmission among human immunodeficiency virus-infected men who have sex with men: Modeling the effect of behavioral and treatment interventions

Salazar-Vizcaya, Luisa
Kouyos, Roger D
Zahnd, Cindy
Wandeler, Gilles
Battegay, Manuel
Darling, Katharine Elizabeth Anna
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Published in Hepatology. 2016, vol. 64, no. 6, p. 1856-1869
Abstract The incidence of hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)-infected men who have sex with men has increased in recent years and is associated with high-risk sexual behavior. Behavioral interventions that target high-risk behavior associated with HCV transmission and treatment with direct-acting antivirals may prevent further HCV infections. We predicted the effect of behavioral and treatment interventions on HCV incidence and prevalence among HIV-infected men who have sex with men up to 2030 using a HCV transmission model parameterized with data from the Swiss HIV Cohort Study. We assessed behavioral interventions associated with further increase, stabilization, and decrease in the size of the population with high-risk behavior. Treatment interventions included increase in treatment uptake and use of direct-acting antivirals. If we assumed that without behavioral interventions high-risk behavior spread further according to the trends observed over the last decade and that the treatment practice did not change, HCV incidence converged to 10.7/100 person-years. All assessed behavioral interventions alone resulted in reduced HCV transmissions. Stabilization of high-risk behavior combined with increased treatment uptake and the use of direct-acting antivirals reduced incidence by 77% (from 2.2 in 2015 to 0.5/100 person-years) and prevalence by 81% (from 4.8% in 2015 to 0.9%) over the next 15 years. Increasing treatment uptake was more effective than increasing treatment efficacy to reduce HCV incidence and prevalence. A decrease in high-risk behavior led to a rapid decline in HCV incidence, independent of treatment interventions.
Keywords AdultAntiviral Agents/therapeutic useBehavior TherapyCohort StudiesHIV Infections/complications/drug therapyHepatitis C/epidemiology/prevention & control/transmissionHomosexualityMaleHumansIncidenceModelsTheoreticalPrevalence
PMID: 27531615
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Article (Published version) (705 Kb) - public document Free access
Research groups Maladies infectieuses et modèles mathématiques (988)
VIH/SIDA (930)
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SALAZAR-VIZCAYA, Luisa et al. Hepatitis C virus transmission among human immunodeficiency virus-infected men who have sex with men: Modeling the effect of behavioral and treatment interventions. In: Hepatology, 2016, vol. 64, n° 6, p. 1856-1869. doi: 10.1002/hep.28769 https://archive-ouverte.unige.ch/unige:111975

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Deposited on : 2018-12-05

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