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BORA-dependent PLK1 regulation: A new weapon for cancer therapy?

Thomas, Yann
Pintard, Lionel
Published in Molecular & Cellular Oncology. 2016, vol. 3, no. 5, p. e1199265
Abstract The mitotic kinase polo like kinase 1 (PLK1) is overexpressed in many cancers and its inhibition slows down proliferation and increases apoptosis in cancer cell lines. Understanding how PLK1 is activated is therefore crucial for the development of novel PLK1 inhibitors with anticancer properties. We recently identified a conserved regulatory loop leading to PLK1 activation that involves cyclin-dependent kinase 1 (CDK1).
PMID: 27857970
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Article (Published version) (1.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group La division asymétrique (847)
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CIRILLO, Luca et al. BORA-dependent PLK1 regulation: A new weapon for cancer therapy?. In: Molecular & Cellular Oncology, 2016, vol. 3, n° 5, p. e1199265. https://archive-ouverte.unige.ch/unige:111961

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Deposited on : 2018-12-05

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