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Scientific article
French

Acide tranexamique dans la prise en charge de l'hémorragie du postpartum : connaissances actuelles

Published inRevue médicale suisse, vol. 14, no. 623, p. 1861-1865
Publication date2018
Abstract

Postpartum haemorrhage (PPH) is the leading cause of maternal death. Primary causes are mostly of obstetrical origin. PPH can be worsened by secondary coagulopathy. This is due to dilution or consumption of coagulation factors and fibrinolysis activation. The use of tranexamic acid, an antifibrinolytic agent, in the management of PPH has been proposed and practiced for several years, following evidence of its efficacy and safety in other settings, including traumatology. The benefit of administration of TXA during PPH has recently been proved by the WOMAN study. This review recalls the physiopathological mechanisms involved in the genesis and aggravation of PPH. It presents the current state of knowledge on the prophylactic and therapeutic efficacy of tranexamic acid in PPH and summarizes the current recommendations in obstetrics.

Citation (ISO format)
PETER, Clarisse et al. Acide tranexamique dans la prise en charge de l’hémorragie du postpartum : connaissances actuelles. In: Revue médicale suisse, 2018, vol. 14, n° 623, p. 1861–1865.
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ISSN of the journal1660-9379
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