Acide tranexamique dans la prise en charge de l&#039;hémorragie du postpartum : connaissances actuelles

Peter, Clarisse; Dereu, Domitille; Casini, Alessandro; Boulvain, Michel; Savoldelli, Georges Louis

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Title		Acide tranexamique dans la prise en charge de l'hémorragie du postpartum : connaissances actuelles
Authors		Peter, Clarisse Dereu, Domitille Casini, Alessandro Boulvain, Michel Savoldelli, Georges Louis
Published in		Revue médicale suisse. 2018, vol. 14, no. 623, p. 1861-1865
Abstract		Postpartum haemorrhage (PPH) is the leading cause of maternal death. Primary causes are mostly of obstetrical origin. PPH can be worsened by secondary coagulopathy. This is due to dilution or consumption of coagulation factors and fibrinolysis activation. The use of tranexamic acid, an antifibrinolytic agent, in the management of PPH has been proposed and practiced for several years, following evidence of its efficacy and safety in other settings, including traumatology. The benefit of administration of TXA during PPH has recently been proved by the WOMAN study. This review recalls the physiopathological mechanisms involved in the genesis and aggravation of PPH. It presents the current state of knowledge on the prophylactic and therapeutic efficacy of tranexamic acid in PPH and summarizes the current recommendations in obstetrics.
Identifiers		PMID: 30329233
Full text		Article (Published version) (154 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		Martinez De Tejada Begona (272) Groupe Savoldelli Georges (simulation) (878)
Citation (ISO format)		PETER, Clarisse et al. Acide tranexamique dans la prise en charge de l'hémorragie du postpartum : connaissances actuelles. In: Revue médicale suisse, 2018, vol. 14, n° 623, p. 1861-1865. https://archive-ouverte.unige.ch/unige:111678