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Title

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

Authors
Jack, Clifford R (Jr)
Bennett, David A
Blennow, Kaj
Carrillo, Maria C
Feldman, Howard H
Hampel, Harald
Jagust, William J
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Published in Neurology. 2016, vol. 87, no. 5, p. 539-47
Abstract Biomarkers have become an essential component of Alzheimer disease (AD) research and because of the pervasiveness of AD pathology in the elderly, the same biomarkers are used in cognitive aging research. A number of current issues suggest that an unbiased descriptive classification scheme for these biomarkers would be useful. We propose the "A/T/N" system in which 7 major AD biomarkers are divided into 3 binary categories based on the nature of the pathophysiology that each measures. "A" refers to the value of a β-amyloid biomarker (amyloid PET or CSF Aβ42); "T," the value of a tau biomarker (CSF phospho tau, or tau PET); and "N," biomarkers of neurodegeneration or neuronal injury ([(18)F]-fluorodeoxyglucose-PET, structural MRI, or CSF total tau). Each biomarker category is rated as positive or negative. An individual score might appear as A+/T+/N-, or A+/T-/N-, etc. The A/T/N system includes the new modality tau PET. It is agnostic to the temporal ordering of mechanisms underlying AD pathogenesis. It includes all individuals in any population regardless of the mix of biomarker findings and therefore is suited to population studies of cognitive aging. It does not specify disease labels and thus is not a diagnostic classification system. It is a descriptive system for categorizing multidomain biomarker findings at the individual person level in a format that is easy to understand and use. Given the present lack of consensus among AD specialists on terminology across the clinically normal to dementia spectrum, a biomarker classification scheme will have broadest acceptance if it is independent from any one clinically defined diagnostic scheme.
Keywords Alzheimer Disease/cerebrospinal fluid/diagnostic imaging/metabolism/pathologyAmyloid beta-Peptides/classificationBiomarkers/metabolismBrain/diagnostic imaging/metabolism/pathologyHumansNerve Degeneration/cerebrospinal fluid/diagnostic imaging/metabolismNeuroimagingPeptide Fragments/classificationtau Proteins/classification
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PMID: 27371494
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Article (Published version) (4.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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JACK, Clifford R (Jr) et al. A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. In: Neurology, 2016, vol. 87, n° 5, p. 539-47. doi: 10.1212/WNL.0000000000002923 https://archive-ouverte.unige.ch/unige:111538

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Deposited on : 2018-11-28

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