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Title

DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4

Authors
Chi, Wei
Li, Jing
He, Baoye
Chai, Xin
Xu, Xiumei
Sun, Xuwu
Jiang, Jingjing
Feng, Peiqiang
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Published in Proceedings of the National Academy of Sciences. 2016, vol. 113, no. 25, p. E3568-76
Abstract Cytokinin is an essential phytohormone that controls various biological processes in plants. A number of response regulators are known to be important for cytokinin signal transduction. ARABIDOPSIS RESPONSE REGULATOR 4 (ARR4) mediates the cross-talk between light and cytokinin signaling through modulation of the activity of phytochrome B. However, the mechanism that regulates the activity and stability of ARR4 is unknown. Here we identify an ATP-independent serine protease, degradation of periplasmic proteins 9 (DEG9), which localizes to the nucleus and regulates the stability of ARR4. Biochemical evidence shows that DEG9 interacts with ARR4, thereby targeting ARR4 for degradation, which suggests that DEG9 regulates the stability of ARR4. Moreover, genetic evidence shows that DEG9 acts upstream of ARR4 and regulates the activity of ARR4 in cytokinin and light-signaling pathways. This study thus identifies a role for a ubiquitin-independent selective protein proteolysis in the regulation of the stability of plant signaling components.
Keywords Arabidopsis Proteins/metabolismCytokinins/metabolismLightSerine Proteases/metabolismSignal TransductionTranscription Factors/metabolism
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PMID: 27274065
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Other version: http://www.pnas.org/content/113/25/E3568.long
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CHI, Wei et al. DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4. In: Proceedings of the National Academy of Sciences, 2016, vol. 113, n° 25, p. E3568-76. https://archive-ouverte.unige.ch/unige:111263

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Deposited on : 2018-11-21

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