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Junctional adhesion molecules and interendothelial junctions

Ozaki, Harunoba
Kita, Toru
Published in Cells tissues organs. 2002, vol. 172, no. 3, p. 152-160
Abstract Similar to epithelia, endothelial cells are linked to each other via intercellular junctional complexes including gap junctions, adherens junctions and tight junctions. While polarized epithelial cells show a high degree of spatial sorting of junctional complexes, endothelia organize their junctions randomly. For this reason the nature of endothelial contacts may be highly adaptable to the need of permeability and leukocyte transmigration. For instance, high endothelial venules (HEVs) in lymphoid organs, where lymphocytes continuously exit the bloodstream, generally show more leaky contacts than brain with its impermeable blood-brain barrier. We recently identified an Ig superfamily molecule named JAM-2 which is specifically expressed in junctions of lymphatic endothelial cells and HEVs. We showed that JAM-2 belongs to the novel CTX molecular family and we now cloned the human equivalent of JAM-2. The presence of JAM-2 at sites of constitutive lymphocyte circulation argues for a role of this molecule in facilitating transmigration. This is supported by the increased transmigration in vitro across endothelial cells overexpressing JAM-2 at intercellular contacts.
Keywords Amino Acid SequenceAnimalsCell Adhesion Molecules/genetics/ metabolismCell LineCell Movement/physiologyEndothelium, Vascular/cytology/metabolismHumansImmunoglobulins/genetics/ metabolismIntercellular Junctions/ metabolismLeukocytes/metabolismLymphocytes/cytology/metabolismMembrane Proteins/genetics/ metabolismMiceMolecular Sequence DataReceptors, Cell SurfaceSequence AlignmentTissue Distribution
PMID: 12476045
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AURRAND-LIONS, Michel et al. Junctional adhesion molecules and interendothelial junctions. In: Cells tissues organs, 2002, vol. 172, n° 3, p. 152-160. doi: 10.1159/000066967

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Deposited on : 2010-08-27

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