Scientific article

Junctional adhesion molecules and interendothelial junctions

Published inCells tissues organs, vol. 172, no. 3, p. 152-160
Publication date2002

Similar to epithelia, endothelial cells are linked to each other via intercellular junctional complexes including gap junctions, adherens junctions and tight junctions. While polarized epithelial cells show a high degree of spatial sorting of junctional complexes, endothelia organize their junctions randomly. For this reason the nature of endothelial contacts may be highly adaptable to the need of permeability and leukocyte transmigration. For instance, high endothelial venules (HEVs) in lymphoid organs, where lymphocytes continuously exit the bloodstream, generally show more leaky contacts than brain with its impermeable blood-brain barrier. We recently identified an Ig superfamily molecule named JAM-2 which is specifically expressed in junctions of lymphatic endothelial cells and HEVs. We showed that JAM-2 belongs to the novel CTX molecular family and we now cloned the human equivalent of JAM-2. The presence of JAM-2 at sites of constitutive lymphocyte circulation argues for a role of this molecule in facilitating transmigration. This is supported by the increased transmigration in vitro across endothelial cells overexpressing JAM-2 at intercellular contacts.

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion Molecules/genetics/ metabolism
  • Cell Line
  • Cell Movement/physiology
  • Endothelium, Vascular/cytology/metabolism
  • Humans
  • Immunoglobulins/genetics/ metabolism
  • Intercellular Junctions/ metabolism
  • Leukocytes/metabolism
  • Lymphocytes/cytology/metabolism
  • Membrane Proteins/genetics/ metabolism
  • Mice
  • Molecular Sequence Data
  • Receptors, Cell Surface
  • Sequence Alignment
  • Tissue Distribution
Affiliation Not a UNIGE publication
Citation (ISO format)
AURRAND-LIONS, Michel et al. Junctional adhesion molecules and interendothelial junctions. In: Cells tissues organs, 2002, vol. 172, n° 3, p. 152–160. doi: 10.1159/000066967
Updates (1)
ISSN of the journal1422-6405

Technical informations

Creation08/27/2010 1:33:48 PM
First validation08/27/2010 1:33:48 PM
Update time03/14/2023 4:02:32 PM
Status update03/14/2023 4:02:32 PM
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