Investigating the association of ventral and dorsal striatal dysfunction during reward anticipation with negative symptoms in patients with schizophrenia and healthy individuals

Stepien, Marta; Manoliu, Andrei; Kubli, Roman; Schneider, Karoline; Tobler, Philippe N; Seifritz, Erich; Herdener, Marcus; Kaiser, Stefan; Kirschner, Matthias

doi:10.1371/journal.pone.0198215

Scientific article

English

Investigating the association of ventral and dorsal striatal dysfunction during reward anticipation with negative symptoms in patients with schizophrenia and healthy individuals

Contributors

Stepien, Marta; Manoliu, Andrei; Kubli, Roman; Schneider, Karoline; Tobler, Philippe N; Seifritz, Erich; Herdener, Marcus; Kaiser, Stefan

; Kirschner, Matthias

Published in

PLOS ONE, vol. 13, no. 6, e0198215

Publication date

2018

Abstract

Negative symptoms are a core feature of schizophrenia and also found in healthy individuals in subclinical forms. According to the current literature the two negative symptom domains, apathy and diminished expression may have different underlying neural mechanisms. Previous observations suggest that striatal dysfunction is associated with apathy in schizophrenia. However, it is unclear whether apathy is specifically related to ventral or dorsal striatal alterations. Here, we investigated striatal dysfunction during reward anticipation in patients with schizophrenia and a non-clinical population, to determine whether it is associated with apathy.

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

UNIGE research groups

Psychopathologie clinique et expérimentale (987)

Citation (ISO format)

STEPIEN, Marta et al. Investigating the association of ventral and dorsal striatal dysfunction during reward anticipation with negative symptoms in patients with schizophrenia and healthy individuals. In: PLOS ONE, 2018, vol. 13, n° 6, p. e0198215. doi: 10.1371/journal.pone.0198215

Article (Published version)

CC BY

Identifiers

PID : unige:111183
DOI : 10.1371/journal.pone.0198215
PMID : 29912880

Journal ISSN

1932-6203

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267downloads

Creation

19/09/2018 15:44:00

First validation

19/09/2018 15:44:00

Update

13/10/2025 18:40:16

Status update

15/03/2023 13:52:45

Last indexation

11/02/2026 10:52:07

Investigating the association of ventral and dorsal striatal dysfunction during reward anticipation with negative symptoms in patients with schizophrenia and healthy individuals

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation