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Scientific article
English

Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency

Published inThe Journal of clinical investigation, vol. 99, no. 7, p. 1699-1703
Publication date1997
Abstract

To evaluate the role of tumor necrosis factor (TNF alpha) in bone loss resulting from estrogen deficiency, the effects of ovariectomy were explored in six-month-old transgenic mice expressing high blood levels of a soluble TNF receptor type I (sTNFR1)-FcIgG3 fusion protein, which neutralizes TNF alpha, and in their nontransgenic littermates used as controls. These transgenic mice were identical to control mice in bone mass (evaluated by bone mineral density and content) and strength. 12 weeks after ovariectomy, the decrease in bone mass and increase in osteocalcin (marker of bone turnover) found in control mice were not observed in transgenic mice, which were not different from sham-operated mice, transgenic or not. This observation suggests a critical role for TNF alpha in the pathogenesis of bone loss induced by estrogen deficiency, a common cause of morbidity in postmenopausal women.

Keywords
  • Animals
  • Bone Density
  • Estrogens/*deficiency
  • Female
  • Interleukin-1/physiology
  • Interleukin-6/physiology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Osteoporosis/*prevention & control
  • Ovariectomy
  • Receptors, Tumor Necrosis Factor/*physiology
Citation (ISO format)
AMMANN, Patrick et al. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. In: The Journal of clinical investigation, 1997, vol. 99, n° 7, p. 1699–1703. doi: 10.1097/00006254-199710000-00018
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ISSN of the journal0021-9738
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