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Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment

Rivero, Guadalupe
Gabilondo, Ane M
García-Sevilla, Jesús A
Morentín, Benito
Meana, J Javier
Published in Schizophrenia Research. 2015, vol. 161, no. 2-3, p. 446-451
Abstract 14-3-3 is a family of conserved regulatory proteins that bind to a multitude of functionally diverse signalling proteins. Various genetic studies and gene expression and proteomic analyses have involved 14-3-3 proteins in schizophrenia (SZ). On the other hand, studies about the status of these proteins in major depressive disorder (MD) are still missing. Immunoreactivity values of cytosolic 14-3-3β and 14-3-3ζ proteins were evaluated by Western blot in prefrontal cortex (PFC) of subjects with schizophrenia (SZ; n=22), subjects with major depressive disorder (MD; n=21) and age-, gender- and postmortem delay-matched control subjects (n=52). The modulation of 14-3-3β and 14-3-3ζ proteins by psychotropic medication was also assessed. The analysis of both proteins in SZ subjects with respect to matched control subjects showed increased 14-3-3β (Δ=33±10%, p<0.05) and 14-3-3ζ (Δ=29±6%, p<0.05) immunoreactivity in antipsychotic-free but not in antipsychotic-treated SZ subjects. Immunoreactivity values of 14-3-3β and 14-3-3ζ were not altered in MD subjects. These results show the specific up-regulation of 14-3-3β and 14-3-3ζ proteins in PFC of SZ subjects and suggest a possible down-regulation of both proteins by antipsychotic treatment.
Keywords 14-3-3 Proteins/metabolismAdultAntidepressive Agents/therapeutic useAntipsychotic Agents/therapeutic useBlotting, WesternCytosol/drug effects/metabolismDepressive Disorder, Major/drug therapy/metabolismFemaleHistocytological Preparation TechniquesHumansMaleMiddle AgedPrefrontal Cortex/drug effects/metabolismSchizophrenia/drug therapy/metabolismSex CharacteristicsTime Factors
PMID: 25549848
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RIVERO, Guadalupe et al. Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment. In: Schizophrenia Research, 2015, vol. 161, n° 2-3, p. 446-451. doi: 10.1016/j.schres.2014.12.014 https://archive-ouverte.unige.ch/unige:111117

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Deposited on : 2018-11-21

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