UNIGE document Scientific Article
previous document  unige:111057  next document
add to browser collection
Title

Determination of urinary catecholamines and metanephrines in cardiac deaths

Authors
Hervet, Tania
Grouzmann, Eric
Published in International Journal of Legal Medicine. 2016, vol. 130, no. 4, p. 995-1001
Abstract The aim of this study was to measure catecholamines and their O-methylated metabolites in urine and vitreous humor collected in cardiac deaths and noncardiac control cases that underwent medicolegal investigations. Our first goal was to assess whether cardiac events of different types are characterized by different catecholamine/metanephrine urine and/or vitreous profiles. Our second goal was to determine whether noncardiac causes of death with different survival intervals are characterized by different catecholamine/metanephrine urine and/or vitreous profiles. Two study groups were prospectively and retrospectively formed, a cardiac death group (including three subgroups, according to the cause of death) and a noncardiac death group (including two subgroups, according to the length of the agonal period). Postmortem angiography, autopsy, histology, toxicology, and biochemistry were performed in all cases. First results seem to indicate that absolute values measured in urine and vitreous for each of the analyzed markers display no significant differences relating to each of the tested cardiac death subgroups. In the control group, absolute concentrations measured in urine and vitreous for each of the analyzed parameters failed to show significant differences relating to the length of agonal period. Our preliminary findings do not seem to confirm the conclusions of former studies and fail to corroborate the usefulness of urine catecholamine and metanephrine analysis to characterize stress response intensity or length of the dying process in the postmortem setting.
Keywords AdolescentAdultAgedCase-Control StudiesCatecholamines/urineDeathDopamine/analogs & derivatives/urineFemaleForensic PathologyHeart Diseases/urineHumansMaleMiddle AgedVitreous Body/chemistryYoung Adult
Identifiers
PMID: 26690910
Full text
Article (Published version) (274 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Silke Grabherr (969)
Citation
(ISO format)
HERVET, Tania et al. Determination of urinary catecholamines and metanephrines in cardiac deaths. In: International Journal of Legal Medicine, 2016, vol. 130, n° 4, p. 995-1001. https://archive-ouverte.unige.ch/unige:111057

7 hits

0 download

Update

Deposited on : 2018-11-21

Export document
Format :
Citation style :