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Title

Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study

Authors
Kazmi, Nabila
Gaunt, Tom R
Relton, Caroline
Published in Clinical Epigenetics. 2017, vol. 9, p. 120
Abstract Eating disorders (ED) are chronic psychiatric disorders, common amongst women of reproductive age. ED in pregnancy are associated with poor nutrition and abnormal intrauterine growth. Increasing evidence also shows offspring of women with ED have adverse developmental and birth outcomes. We sought to carry out the first study investigating DNA methylation in offspring of women with ED. We compared cord blood DNA methylation in offspring of women with active ED (n = 21), past ED (n = 43) and age- and social class-matched controls (n = 126) as part of the Avon Longitudinal Study of Parents and Children.
Keywords AdultDNA MethylationFeeding and Eating Disorders/geneticsFemaleFetal Blood/chemistryGalectin 2/geneticsGenome-Wide Association StudyHumansLinear ModelsLongitudinal StudiesMaleNerve Tissue Proteins/geneticsOxidoreductases Acting on CH-CH Group Donors/geneticsPregnancyPrenatal Exposure Delayed Effects/geneticsProspective StudiesYoung Adult
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PMID: 29093763
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Article (Published version) (407 Kb) - public document Free access
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Research group Troubles de l'alimentation, des comportements alimentaires et autres troubles associés (996)
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(ISO format)
KAZMI, Nabila et al. Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study. In: Clinical Epigenetics, 2017, vol. 9, p. 120. https://archive-ouverte.unige.ch/unige:111047

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Deposited on : 2018-11-21

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