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Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study |
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Published in | Clinical Epigenetics. 2017, vol. 9, 120 | |
Abstract | Eating disorders (ED) are chronic psychiatric disorders, common amongst women of reproductive age. ED in pregnancy are associated with poor nutrition and abnormal intrauterine growth. Increasing evidence also shows offspring of women with ED have adverse developmental and birth outcomes. We sought to carry out the first study investigating DNA methylation in offspring of women with ED. We compared cord blood DNA methylation in offspring of women with active ED (n = 21), past ED (n = 43) and age- and social class-matched controls (n = 126) as part of the Avon Longitudinal Study of Parents and Children. | |
Keywords | Adult — DNA Methylation — Feeding and Eating Disorders/genetics — Female — Fetal Blood/chemistry — Galectin 2/genetics — Genome-Wide Association Study — Humans — Linear Models — Longitudinal Studies — Male — Nerve Tissue Proteins/genetics — Oxidoreductases Acting on CH-CH Group Donors/genetics — Pregnancy — Prenatal Exposure Delayed Effects/genetics — Prospective Studies — Young Adult | |
Identifiers | PMID: 29093763 | |
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Research group | Troubles de l'alimentation, des comportements alimentaires et autres troubles associés (996) | |
Citation (ISO format) | KAZMI, Nabila et al. Maternal eating disorders affect offspring cord blood DNA methylation: a prospective study. In: Clinical Epigenetics, 2017, vol. 9, p. 120. doi: 10.1186/s13148-017-0418-3 https://archive-ouverte.unige.ch/unige:111047 |