Multiple or aggravated forms of discrimination have not been properly dealt with in health systems. This article reports on the findings of three case studies conducted in Australia, Mexico, and New Zealand that look at the experiences of Indigenous persons with disabilities accessing health care. The findings show that health systems in these three countries have not sufficiently addressed barriers to health care arising from aggravated forms of discrimination, such as the intersection between disability and indigeneity. Findings reveal also how both interpersonal and systematic discrimination emerged from protocols and procedures that often had no discriminatory intent but had a disproportionately negative impact on populations such as Indigenous persons with disabilities. The article also offers recommendations on how to improve awareness and cultural competency to tackle discriminatory practices in order to improve health access and effective adherence of Indigenous peoples in health care settings.