G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

Lorenzen, Emily; Ceraudo, Emilie; Berchiche, Yamina A.; Rico, Carlos A.; Fuerstenberg, Alexandre; Sakmar, Thomas P.; Huber, Thomas

doi:10.1126/scisignal.aao6152

Scientific article

Open access

English

G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

ContributorsLorenzen, Emily; Ceraudo, Emilie; Berchiche, Yamina A.; Rico, Carlos A.; Fuerstenberg, Alexandre

; Sakmar, Thomas P.; Huber, Thomas

Published inScience Signaling, vol. 11, no. 552, eaao6152

Publication date2018

Abstract

Chemokine analogs targeting CCR5 were identified that show G protein-subtype ligand bias and can enhance and attenuate CCR5-mediated Gq signaling while maintaining Gi/o signaling.

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie minérale, analytique et appliquée

Citation (ISO format)

LORENZEN, Emily et al. G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs. In: Science Signaling, 2018, vol. 11, n° 552, p. eaao6152. doi: 10.1126/scisignal.aao6152

Article (Accepted version)

Identifiers

PID : unige:110713
DOI : 10.1126/scisignal.aao6152

ISSN of the journal1937-9145

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Creation11/12/2018 11:20:00 AM

First validation11/12/2018 11:20:00 AM

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G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

Chemokine analogs targeting CCR5 were identified that show G protein-subtype ligand bias and can enhance and attenuate CCR5-mediated Gq signaling while maintaining Gi/o signaling.

Technical informations