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IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro

Boutet, Marie-Astrid
Najm, Aurélie
Bart, Géraldine
Brion, Régis
Touchais, Sophie
Trichet, Valérie
Layrolle, Pierre
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Published in Annals of the rheumatic diseases. 2017, vol. 76, no. 7, p. 1304-1312
Abstract Interleukin (IL)-38 is a newly characterised cytokine that belongs to the IL-1 family. This cytokine is expressed in the rheumatoid arthritis (RA) synovial tissue and IL-38 deficient mice have exacerbated arthritis. Here, we analysed the effect of IL-38 overexpression in the joints of arthritic mice, in human macrophages and synovial fibroblasts in vitro.
Keywords AnimalsArthritis, Experimental/genetics/immunologyArthritis, Rheumatoid/immunologyBlotting, WesternBone and Bones/diagnostic imagingCartilage, Articular/diagnostic imagingCell LineCulture Media, ConditionedEnzyme-Linked Immunosorbent AssayFibroblasts/immunologyHumansImmunohistochemistryIn Vitro TechniquesInterleukin-17/genetics/immunologyInterleukin-23/genetics/immunologyInterleukin-6/genetics/immunologyInterleukins/genetics/immunologyMacrophages/immunologyMiceReal-Time Polymerase Chain ReactionSynovial Membrane/cytologyTh17 Cells/immunologyTranscriptomeTumor Necrosis Factor-alpha/genetics/immunologyX-Ray Microtomography
PMID: 28288964
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Article (Published version) (5.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Biologie des cytokines de la famille de l'interleukine-1 (1022)
Mécanisme de l'inflammation articulaire (44)
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BOUTET, Marie-Astrid et al. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. In: Annals of the Rheumatic Diseases, 2017, vol. 76, n° 7, p. 1304-1312. doi: 10.1136/annrheumdis-2016-210630 https://archive-ouverte.unige.ch/unige:110658

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Deposited on : 2018-11-12

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