IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro

Boutet, Marie-Astrid; Najm, Aurélie; Bart, Géraldine; Brion, Régis; Touchais, Sophie; Trichet, Valérie; Layrolle, Pierre; Gabay, Cem; Palmer-Lourenco, Gaby; Blanchard, Frédéric; Le Goff, Benoit

doi:10.1136/annrheumdis-2016-210630

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Title		IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro
Authors		Boutet, Marie-Astrid Najm, Aurélie Bart, Géraldine Brion, Régis Touchais, Sophie Trichet, Valérie Layrolle, Pierre Gabay, Cem Palmer-Lourenco, Gaby Blanchard, Frédéric Le Goff, Benoit show all authors [1 - 11]
Published in		Annals of the Rheumatic Diseases. 2017, vol. 76, no. 7, p. 1304-1312
Abstract		Interleukin (IL)-38 is a newly characterised cytokine that belongs to the IL-1 family. This cytokine is expressed in the rheumatoid arthritis (RA) synovial tissue and IL-38 deficient mice have exacerbated arthritis. Here, we analysed the effect of IL-38 overexpression in the joints of arthritic mice, in human macrophages and synovial fibroblasts in vitro.
Keywords		Animals — Arthritis, Experimental/genetics/immunology — Arthritis, Rheumatoid/immunology — Blotting, Western — Bone and Bones/diagnostic imaging — Cartilage, Articular/diagnostic imaging — Cell Line — Culture Media, Conditioned — Enzyme-Linked Immunosorbent Assay — Fibroblasts/immunology — Humans — Immunohistochemistry — In Vitro Techniques — Interleukin-17/genetics/immunology — Interleukin-23/genetics/immunology — Interleukin-6/genetics/immunology — Interleukins/genetics/immunology — Macrophages/immunology — Mice — Real-Time Polymerase Chain Reaction — Synovial Membrane/cytology — Th17 Cells/immunology — Transcriptome — Tumor Necrosis Factor-alpha/genetics/immunology — X-Ray Microtomography
Identifiers		DOI: 10.1136/annrheumdis-2016-210630 PMID: 28288964
Full text		Article (Published version) (5.3 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research groups		Mécanisme de l'inflammation articulaire (44) Biologie des cytokines de la famille de l'interleukine-1 (1022)
Citation (ISO format)		BOUTET, Marie-Astrid et al. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. In: Annals of the Rheumatic Diseases, 2017, vol. 76, n° 7, p. 1304-1312. doi: 10.1136/annrheumdis-2016-210630 https://archive-ouverte.unige.ch/unige:110658