IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro

Boutet, Marie-Astrid; Najm, Aurélie; Bart, Géraldine; Brion, Régis; Touchais, Sophie; Trichet, Valérie; Layrolle, Pierre; Gabay, Cem; Palmer-Lourenco, Gaby; Blanchard, Frédéric; Le Goff, Benoit

doi:10.1136/annrheumdis-2016-210630

Scientific article

English

IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro

ContributorsBoutet, Marie-Astrid; Najm, Aurélie; Bart, Géraldine; Brion, Régis; Touchais, Sophie; Trichet, Valérie; Layrolle, Pierre; Gabay, Cem; Palmer-Lourenco, Gaby

; Blanchard, Frédéric; Le Goff, Benoit

Published inAnnals of the Rheumatic Diseases, vol. 76, no. 7, p. 1304-1312

Publication date2017

Abstract

Interleukin (IL)-38 is a newly characterised cytokine that belongs to the IL-1 family. This cytokine is expressed in the rheumatoid arthritis (RA) synovial tissue and IL-38 deficient mice have exacerbated arthritis. Here, we analysed the effect of IL-38 overexpression in the joints of arthritic mice, in human macrophages and synovial fibroblasts in vitro.

Keywords

Animals
Arthritis, Experimental/genetics/immunology
Arthritis, Rheumatoid/immunology
Blotting, Western
Bone and Bones/diagnostic imaging
Cartilage, Articular/diagnostic imaging
Cell Line
Culture Media, Conditioned
Enzyme-Linked Immunosorbent Assay
Fibroblasts/immunology
Humans
Immunohistochemistry
In Vitro Techniques
Interleukin-17/genetics/immunology
Interleukin-23/genetics/immunology
Interleukin-6/genetics/immunology
Interleukins/genetics/immunology
Macrophages/immunology
Mice
Real-Time Polymerase Chain Reaction
Synovial Membrane/cytology
Th17 Cells/immunology
Transcriptome
Tumor Necrosis Factor-alpha/genetics/immunology
X-Ray Microtomography

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Citation (ISO format)

BOUTET, Marie-Astrid et al. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. In: Annals of the Rheumatic Diseases, 2017, vol. 76, n° 7, p. 1304–1312. doi: 10.1136/annrheumdis-2016-210630

Article (Published version)

Identifiers

PID : unige:110658
DOI : 10.1136/annrheumdis-2016-210630
PMID : 28288964

Journal ISSN0003-4967

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IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro

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