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Scientific article
English

IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro

Published inAnnals of the Rheumatic Diseases, vol. 76, no. 7, p. 1304-1312
Publication date2017
Abstract

Interleukin (IL)-38 is a newly characterised cytokine that belongs to the IL-1 family. This cytokine is expressed in the rheumatoid arthritis (RA) synovial tissue and IL-38 deficient mice have exacerbated arthritis. Here, we analysed the effect of IL-38 overexpression in the joints of arthritic mice, in human macrophages and synovial fibroblasts in vitro.

Keywords
  • Animals
  • Arthritis, Experimental/genetics/immunology
  • Arthritis, Rheumatoid/immunology
  • Blotting, Western
  • Bone and Bones/diagnostic imaging
  • Cartilage, Articular/diagnostic imaging
  • Cell Line
  • Culture Media, Conditioned
  • Enzyme-Linked Immunosorbent Assay
  • Fibroblasts/immunology
  • Humans
  • Immunohistochemistry
  • In Vitro Techniques
  • Interleukin-17/genetics/immunology
  • Interleukin-23/genetics/immunology
  • Interleukin-6/genetics/immunology
  • Interleukins/genetics/immunology
  • Macrophages/immunology
  • Mice
  • Real-Time Polymerase Chain Reaction
  • Synovial Membrane/cytology
  • Th17 Cells/immunology
  • Transcriptome
  • Tumor Necrosis Factor-alpha/genetics/immunology
  • X-Ray Microtomography
Citation (ISO format)
BOUTET, Marie-Astrid et al. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. In: Annals of the Rheumatic Diseases, 2017, vol. 76, n° 7, p. 1304–1312. doi: 10.1136/annrheumdis-2016-210630
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0003-4967
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