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Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis

Santiago, Llipsy
Menaa, Cheikh
Arias, Maykel
Martin, Praxedis Sina
Jaime-Sánchez, Paula
Metkar, Sunil
Comas, Laura
Erill, Nadina
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Published in Arthritis and Rheumatology. 2017, vol. 69, no. 2, p. 320-334
Abstract Granzyme A (GzmA) levels are elevated in the plasma and synovium of patients with rheumatoid arthritis (RA), suggesting involvement of this protease in the pathogenesis of the disease. GzmA contributes to sepsis by regulating the production of proinflammatory cytokines. The purpose of this study was to evaluate the contribution of GzmA to the pathogenesis of RA in vivo and to examine the possibility that GzmA acting via tumor necrosis factor (TNF) stimulates osteoclastogenesis.
Keywords AnimalsArthritis, Experimental/enzymology/etiologyArthritis, Rheumatoid/enzymology/etiologyFemaleGranzymes/physiologyMiceMice, Inbred C57BLOsteogenesis/physiologyTumor Necrosis Factor-alpha/physiology
PMID: 27598995
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Research group Mécanisme de l'inflammation articulaire (44)
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SANTIAGO, Llipsy et al. Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis. In: Arthritis and Rheumatology, 2017, vol. 69, n° 2, p. 320-334. doi: 10.1002/art.39857 https://archive-ouverte.unige.ch/unige:110654

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Deposited on : 2018-11-12

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