Several philosophers, both in Buddhist and Western philosophy, claim that the self does not exist. The no-self view may, at first glance, appear to be a reason to believe that life is meaningless. In the present article, I argue indirectly in favor of the no-self view by showing that it does not entail that life is meaningless. I then examine Buddhism and argue, further, that the no-self view may even be construed as partially grounding an account of the meaning of life.