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Scientific article
English

3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium

Published inJournal of ethnopharmacology, vol. 103, no. 3, p. 461-467
Publication date2006
Abstract

A new prenylated salicylic acid derivative, 3-farnesyl-2-hydroxy benzoic acid (1), was isolated from the leaves of Piper multiplinervium C. DC. (Piperaceae). It showed anti-Helicobacter pylori activity (MIC 37.5 mu g/ml) and antimicrobial activity at MICs between 2.5 and 5 mu g/ml against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Mycobacterium smegmatis, Pseudonionas aeruginosa and Candida albicans. Its structure was elucidated by means of MS, H-1 and C-13 NMR. The ethnomedical claim of Piper multiplinervium to treat stomach aches by the Kuna Indians of Panama may be justified by anti-Helicobacter pylori activity of its MeOH extract. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Keywords
  • Piper multiplinervium
  • Antimicrobial
  • Helicobacter pylori
  • Prenylated 2-hydroxybenzoic acid
  • Kuna Indians
Citation (ISO format)
RUEGG, T. et al. 3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium. In: Journal of ethnopharmacology, 2006, vol. 103, n° 3, p. 461–467. doi: 10.1016/j.jep.2005.09.014
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ISSN of the journal0378-8741
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