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Scientific article
English

Natural product inhibitors of acetylcholinesterase

Published inCurrent organic chemistry, vol. 10, p. 825-847
Publication date2006
Abstract

Various natural products, such as physostigmine, have long been recognized as inhibitors of the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the treatment of Alzheimer's disease by the blockage of acetylcholine degradation, attempts to find other inhibitors of the enzyme have multiplied, leading to promising candidates such as huperzine A. In this review, a listing is presented of natural product inhibitors, both alkaloid and non-alkaloid in origin. These have been isolated from plant, animal and microbial sources. Details of current testing methods on cholinesterases are given, including solution assays and screening techniques by TLC and HPLC.

Keywords
  • LAVANDULAEFOLIA ESSENTIAL OIL
  • IMMOBILIZED-ENZYME REACTOR
  • INDUCED LEARNING IMPAIRMENT
  • THIN-LAYER-CHROMATOGRAPHY
  • HEALTHY-YOUNG VOLUNTEERS
  • FLOW-INJECTION ANALYSIS
  • 14-UNIT T-MAZE
  • ALZHEIMERS-DISEASE
  • HUPERZINE-A
  • ASPERGILLUS-TERREUS
Citation (ISO format)
HOSTETTMANN, Kurt et al. Natural product inhibitors of acetylcholinesterase. In: Current organic chemistry, 2006, vol. 10, p. 825–847.
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Article (Published version)
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Identifiers
  • PID : unige:11025
ISSN of the journal1385-2728
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