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Title

Natural product inhibitors of acetylcholinesterase

Authors
Borloz, A.
Marston, Andrew
Published in Current Organic Chemistry. 2006, vol. 10, p. 825-847
Abstract Various natural products, such as physostigmine, have long been recognized as inhibitors of the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the treatment of Alzheimer's disease by the blockage of acetylcholine degradation, attempts to find other inhibitors of the enzyme have multiplied, leading to promising candidates such as huperzine A. In this review, a listing is presented of natural product inhibitors, both alkaloid and non-alkaloid in origin. These have been isolated from plant, animal and microbial sources. Details of current testing methods on cholinesterases are given, including solution assays and screening techniques by TLC and HPLC.
Keywords LAVANDULAEFOLIA ESSENTIAL OILIMMOBILIZED-ENZYME REACTORINDUCED LEARNING IMPAIRMENTTHIN-LAYER-CHROMATOGRAPHYHEALTHY-YOUNG VOLUNTEERSFLOW-INJECTION ANALYSIS14-UNIT T-MAZEALZHEIMERS-DISEASEHUPERZINE-AASPERGILLUS-TERREUS
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HOSTETTMANN, Kurt et al. Natural product inhibitors of acetylcholinesterase. In: Current Organic Chemistry, 2006, vol. 10, p. 825-847. https://archive-ouverte.unige.ch/unige:11025

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Deposited on : 2010-08-27

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