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Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis

Lapérine, Olivier
Cloitre, Alexandra
Caillon, Jocelyne
Huck, Olivier
Bugueno, Isaac Maximiliano
Pilet, Paul
Sourice, Sophie
Le Tilly, Elodie
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Published in PLOS ONE. 2016, vol. 11, no. 12, p. e0168080
Abstract Chronic Periodontitis (CP) is an inflammatory disease of bacterial origin that results in alveolar bone destruction. Porphyromonas gingivalis (Pg), one of the main periopathogens, initiates an inflammatory cascade by host immune cells thereby increasing recruitment and activity of osteoclasts, the bone resorbing cells, through enhanced production of the crucial osteoclastogenic factor, RANK-L. Antibodies directed against some cytokines (IL-1β, IL-6 and TNF-α) failed to exhibit convincing therapeutic effect in CP. It has been suggested that IL-33, could be of interest in CP.
Keywords AdolescentAdultAlveolar Bone Loss/diagnostic imaging/genetics/metabolismAnimalsBacteroidaceae Infections/complications/genetics/metabolismCellsCulturedChronic Periodontitis/complications/genetics/metabolism/microbiologyDisease ModelsAnimalFemaleGenetic Predisposition to DiseaseHumansInterleukin-33/genetics/metabolismMaleMiceMiddle AgedPorphyromonas gingivalis/pathogenicityRANK Ligand/genetics/metabolismUp-RegulationX-Ray MicrotomographyYoung Adult
PMID: 27992569
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Article (Published version) (2.6 MB) - public document Free access
Research groups Mécanisme de l'inflammation articulaire (44)
Biologie des cytokines de la famille de l'interleukine-1 (1022)
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LAPÉRINE, Olivier et al. Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis. In: PLOS ONE, 2016, vol. 11, n° 12, p. e0168080. doi: 10.1371/journal.pone.0168080 https://archive-ouverte.unige.ch/unige:110105

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Deposited on : 2018-10-30

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