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Title

Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

Authors
Béguelin, C
Vázquez, M
Bertschi, M
de Jong, D
Gutbrod, K
Rauch, A
Cusini, A
Published in Open Forum Infectious Diseases. 2016, vol. 3, no. 1, p. ofv210
Abstract In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.
Identifiers
PMID: 26885540
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Article (Published version) (244 Kb) - public document Free access
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Research group Groupe Laurent Kaiser (virologie clinique) (668)
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BÉGUELIN, C et al. Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1. In: Open Forum Infectious Diseases, 2016, vol. 3, n° 1, p. ofv210. https://archive-ouverte.unige.ch/unige:110104

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Deposited on : 2018-10-30

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