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Title

Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure

Authors
Desgranges, Stéphane
Celicanin, Zarko
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Published in Journal of Magnetic Resonance. 2018, vol. 295, p. 27-37
Abstract Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging contrast agents, or as delivery vectors for pharmaceuticals. They also demonstrated capability to enhance the efficiency of high intensity focused ultrasound thermo-therapy. In the context of new biomedical applications we investigated perfluorooctyl bromide (PFOB) theranostic droplets using 19F NMR. Each droplet contains biocompatible fluorinated surfactants composed of a polar Tris(hydroxymethyl)aminomethane head unit and hydrophobic perfluorinated tail (abbreviated as F-TAC). The influence of the droplet size on the oxygen loading capacity was determined from longitudinal relaxation (T1) data of 19F NMR signal.
Identifiers
PMID: 30096550
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Structures
Projects FNS: 31NM30_152045
FP7: EURONANOMED II
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LORTON, Orane et al. Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure. In: Journal of Magnetic Resonance, 2018, vol. 295, p. 27-37. https://archive-ouverte.unige.ch/unige:110037

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Deposited on : 2018-10-30

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