Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure

Lorton, Orane; Hyacinthe, Jean-Noël; Desgranges, Stéphane; Gui Levy, Laura; Klauser, Antoine; Celicanin, Zarko; Crowe, Lindsey; Lazeyras, François; Allémann, Eric; Taulier, Nicolas; Contino-Pépin, Christiane; Salomir, Rares Vincent

doi:10.1016/j.jmr.2018.07.019

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Title		Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure
Authors		Lorton, Orane Hyacinthe, Jean-Noël Desgranges, Stéphane Gui Levy, Laura Klauser, Antoine Celicanin, Zarko Crowe, Lindsey Lazeyras, François Allémann, Eric Taulier, Nicolas Contino-Pépin, Christiane Salomir, Rares Vincent show all authors [1 - 12]
Published in		Journal of Magnetic Resonance. 2018, vol. 295, p. 27-37
Abstract		Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging contrast agents, or as delivery vectors for pharmaceuticals. They also demonstrated capability to enhance the efficiency of high intensity focused ultrasound thermo-therapy. In the context of new biomedical applications we investigated perfluorooctyl bromide (PFOB) theranostic droplets using 19F NMR. Each droplet contains biocompatible fluorinated surfactants composed of a polar Tris(hydroxymethyl)aminomethane head unit and hydrophobic perfluorinated tail (abbreviated as F-TAC). The influence of the droplet size on the oxygen loading capacity was determined from longitudinal relaxation (T1) data of 19F NMR signal.
Identifiers		DOI: 10.1016/j.jmr.2018.07.019 PMID: 30096550
Full text		Article (Published version) (1.6 MB) - Limited access to UNIGE
Structures		Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949) Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) (539)
Projects		FNS: 31NM30_152045 FP7: EURONANOMED II
Citation (ISO format)		LORTON, Orane et al. Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure. In: Journal of Magnetic Resonance, 2018, vol. 295, p. 27-37. doi: 10.1016/j.jmr.2018.07.019 https://archive-ouverte.unige.ch/unige:110037