en
Scientific article
English

Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure

Published inJournal of Magnetic Resonance, vol. 295, p. 27-37
Publication date2018
Abstract

Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging contrast agents, or as delivery vectors for pharmaceuticals. They also demonstrated capability to enhance the efficiency of high intensity focused ultrasound thermo-therapy. In the context of new biomedical applications we investigated perfluorooctyl bromide (PFOB) theranostic droplets using 19F NMR. Each droplet contains biocompatible fluorinated surfactants composed of a polar Tris(hydroxymethyl)aminomethane head unit and hydrophobic perfluorinated tail (abbreviated as F-TAC). The influence of the droplet size on the oxygen loading capacity was determined from longitudinal relaxation (T1) data of 19F NMR signal.

Funding
Citation (ISO format)
LORTON, Orane et al. Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressure. In: Journal of Magnetic Resonance, 2018, vol. 295, p. 27–37. doi: 10.1016/j.jmr.2018.07.019
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1090-7807
389views
1downloads

Technical informations

Creation09/04/2018 9:48:00 AM
First validation09/04/2018 9:48:00 AM
Update time03/15/2023 1:08:40 PM
Status update03/15/2023 1:08:40 PM
Last indexation05/02/2024 9:49:53 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack