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Title

Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits

Authors
Perrotta, Gaetano
Bonnier, Guillaume
Meskaldji, Djalel-Eddine
Romascano, David
Aydarkhanov, Ruslan
Daducci, Alessandro
Simioni, Samanta
Cavassini, Matthias
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Published in Annals of Clinical and Translational Neurology. 2017, vol. 4, no. 12, p. 915-920
Abstract Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brain inflammation and damage, we performed T1/T2* relaxometry and magnetization transfer imaging in 17 aviremic HIV+ patients with minor neurocognitive disorders enrolled on a crossed over randomized rivastigmine trial. Rivastigmine therapy was associated with changes in MRI metrics indicating a decrease in brain water content (i.e., edema reabsorption) and/or reduced demyelination/axonal damage. Furthermore, MRI changes correlated with cognitive improvement on rivastigmine therapy.
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PMID: 29296621
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PERROTTA, Gaetano et al. Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits. In: Annals of Clinical and Translational Neurology, 2017, vol. 4, n° 12, p. 915-920. https://archive-ouverte.unige.ch/unige:110027

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Deposited on : 2018-10-30

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