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Title

How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

Authors
Rehrauer, Hubert
Wu, Licun
Blum, Walter
Pecze, Lazslo
Henzi, Thomas
Aquino, Catherine
Vrugt, Bart
show hidden authors show all authors [1 - 11]
Published in Oncogene. 2018, vol. 37, no. 20, p. 2645-2659
Abstract Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue showed increased levels of single-nucleotide variations, with an RNA-editing signature, which were even higher in the tumor samples. Subcutaneous injection of asbestos-treated, but tumor-free mice with syngeneic mesothelioma tumor cells resulted in a significantly higher incidence of tumor growth when compared to naïve mice supporting the role of the environment in tumor progression.
Keywords cancermesotheliomaasbestosTumor-associated macrophagesmesothelial precursor cellsYAP/TAZ-dependent gene transcription
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Research group Mésothéliome pleural malin (944)
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REHRAUER, Hubert et al. How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations. In: Oncogene, 2018, vol. 37, n° 20, p. 2645-2659. https://archive-ouverte.unige.ch/unige:110021

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Deposited on : 2018-10-30

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