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Title

AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

Authors
Carneiro, Lionel
Asrih, Mohamed
Repond, Cendrine
Sempoux, Christine
Stehle, Jean-Christophe
Leloup, Corinne
Pellerin, Luc
Published in Molecular Metabolism. 2017, vol. 6, no. 12, p. 1625-1633
Abstract Hepatic steatosis is the first step leading to non-alcoholic fatty liver disease, which represents a major complication of obesity. Here, we show that MCT1 haploinsufficient mice resist to hepatic steatosis development when fed a high fat diet. They exhibit a reduced hepatic capacity to metabolize monocarboxylates such as lactate compared to wildtype mice.
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PMID: 29092796
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CARNEIRO, Lionel et al. AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. In: Molecular Metabolism, 2017, vol. 6, n° 12, p. 1625-1633. https://archive-ouverte.unige.ch/unige:109655

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Deposited on : 2018-10-23

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