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Scientific article
English

AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

Published inMolecular Metabolism, vol. 6, no. 12, p. 1625-1633
Publication date2017
Abstract

Hepatic steatosis is the first step leading to non-alcoholic fatty liver disease, which represents a major complication of obesity. Here, we show that MCT1 haploinsufficient mice resist to hepatic steatosis development when fed a high fat diet. They exhibit a reduced hepatic capacity to metabolize monocarboxylates such as lactate compared to wildtype mice.

Citation (ISO format)
CARNEIRO, Lionel et al. AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. In: Molecular Metabolism, 2017, vol. 6, n° 12, p. 1625–1633. doi: 10.1016/j.molmet.2017.10.005
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ISSN of the journal2212-8778
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Creation08/31/2018 3:18:00 PM
First validation08/31/2018 3:18:00 PM
Update time03/15/2023 8:49:57 AM
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