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Scientific article
English

Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

ContributorsRajput, B.; Marshall, A.; Killary, A. M.; Lalley, P. A.; Naylor, S. L.; Belin, Dominique; Rickles, R. J.; Strickland, S.
Published inSomatic cell and molecular genetics, vol. 13, no. 5, p. 581-586
Publication date1987
Abstract

The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.

Keywords
  • Animals
  • Chromosome Mapping
  • DNA/genetics
  • DNA Restriction Enzymes
  • Humans
  • Hybrid Cells
  • Linkage (Genetics)
  • Mice
  • Nucleic Acid Hybridization
  • Rats
  • Tissue Plasminogen Activator/ genetics
  • Urokinase-Type Plasminogen Activator/ genetics
Affiliation entities Not a UNIGE publication
Citation (ISO format)
RAJPUT, B. et al. Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. In: Somatic cell and molecular genetics, 1987, vol. 13, n° 5, p. 581–586. doi: 10.1007/BF01534500
Identifiers
Additional URL for this publicationhttp://www.springerlink.com/content/q080n467339j35p4/
Journal ISSN0740-7750
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