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Title

Myofibroblastes et membranes fibrovasculaires rétiniennes

Authors
Pournaras, C. J.
Kapetanios, A. D.
Redard, M.
Published in Klinische Monatsblätter für Augenheilkunde. 1998, vol. 212, no. 5, p. 356-358
Abstract INTRODUCTION: Epiretinal tissue proliferations occurring during the evolution of ischemic microangiopathies or preretinal diseases are tough to cause retinal detachment by traction mechanisms. Cellular migration/proliferations and finally contraction are tough to be the pathogenic element. Myofibroblasts are contractile cells having features intermediate between those of the fibroblasts and smooth muscle. We conducted a study to explore whether such cells are present in preretinal membranes. MATERIALS AND METHODS: 8 membranes, preelevated during vitrectomy for proliferative vitreoretinopathy or diabetic proliferative vitreoretinopathy, were analysed with immunostaining technique searching for alpha-actine smooth muscle, desmine, which are specific markers for myofibroblasts and TGF-beta1, that is considered as the mean factor promoting the transformation of fibroblasts into myofibroblasts. RESULTS: All the histological preparation showed abundant staining with antibody against alpha-actine smooth muscle, desmine and TGF-beta1. CONCLUSIONS: Myofibroblasts are one of the major cellular element of preretinal membranes. They are scattered throughout the membrane and seem to account for their contractile properties.
Keywords Actins/metabolismCell Division/ physiologyCell Movement/physiologyDesmin/metabolismDiabetic Retinopathy/ pathologyEpiretinal Membrane/ pathologyFibroblasts/pathologyHumansMyosins/metabolismRetinal Detachment/pathologyTransforming Growth Factor beta/metabolismVitreoretinopathy, Proliferative/ pathology
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PMID: 9677578
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POURNARAS, C. J. et al. Myofibroblastes et membranes fibrovasculaires rétiniennes. In: Klinische Monatsblätter für Augenheilkunde, 1998, vol. 212, n° 5, p. 356-358. https://archive-ouverte.unige.ch/unige:10957

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Deposited on : 2010-08-26

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