Myofibroblastes et membranes fibrovasculaires rétiniennes
|Published in||Klinische Monatsblätter für Augenheilkunde. 1998, vol. 212, no. 5, p. 356-358|
|Abstract||INTRODUCTION: Epiretinal tissue proliferations occurring during the evolution of ischemic microangiopathies or preretinal diseases are tough to cause retinal detachment by traction mechanisms. Cellular migration/proliferations and finally contraction are tough to be the pathogenic element. Myofibroblasts are contractile cells having features intermediate between those of the fibroblasts and smooth muscle. We conducted a study to explore whether such cells are present in preretinal membranes. MATERIALS AND METHODS: 8 membranes, preelevated during vitrectomy for proliferative vitreoretinopathy or diabetic proliferative vitreoretinopathy, were analysed with immunostaining technique searching for alpha-actine smooth muscle, desmine, which are specific markers for myofibroblasts and TGF-beta1, that is considered as the mean factor promoting the transformation of fibroblasts into myofibroblasts. RESULTS: All the histological preparation showed abundant staining with antibody against alpha-actine smooth muscle, desmine and TGF-beta1. CONCLUSIONS: Myofibroblasts are one of the major cellular element of preretinal membranes. They are scattered throughout the membrane and seem to account for their contractile properties.|
|Keywords||Actins/metabolism — Cell Division/ physiology — Cell Movement/physiology — Desmin/metabolism — Diabetic Retinopathy/ pathology — Epiretinal Membrane/ pathology — Fibroblasts/pathology — Humans — Myosins/metabolism — Retinal Detachment/pathology — Transforming Growth Factor beta/metabolism — Vitreoretinopathy, Proliferative/ pathology|
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|POURNARAS, C. J. et al. Myofibroblastes et membranes fibrovasculaires rétiniennes. In: Klinische Monatsblätter für Augenheilkunde, 1998, vol. 212, n° 5, p. 356-358. https://archive-ouverte.unige.ch/unige:10957|