Highlights
Home
Titles listPlasmodium falciparum synthesizes O-glycosylated glycoproteins containing O-linked N-acetylglucosamine
Titles listPlasmodium falciparum synthesizes O-glycosylated glycoproteins containing O-linked N-acetylglucosamine
Scientific Article
unige:10951 
 |
Plasmodium falciparum synthesizes O-glycosylated glycoproteins containing O-linked N-acetylglucosamine |
|
| Authors | ||
| Published in | Biochemistry international. 1992, vol. 27, no. 1, p. 55-64 | |
| Abstract | Asexual blood forms of the human malaria parasite, Plasmodium falciparum, synthesize a major glycosylated 195 kDa protein that has been considered for the development of a vaccine. beta-Elimination-borohydride reduction of the 195 kDa glycoprotein and its 16 kDa processed product after metabolic labeling of their carbohydrates, showed the presence of derived, labeled glucosaminitol and alanine. This suggests that the 195 and 16 kDa glycoproteins contain distinct O-glycosyl linkages and that N-acetylglucosamine and serine residues are involved in the attachment of carbohydrate moieties to the protein core. Endo-O-glycanase treatment of total glycoproteins shows that O-glycosidycally-linked sugars represent a major carbohydrate moiety in P. falciparum glycoproteins. | |
| Keywords | Acetylglucosamine/chemistry/ metabolism — Animals — Chromatography, Paper — Electrophoresis, Polyacrylamide Gel — Glycoproteins/ biosynthesis/chemistry/metabolism — Glycosylation — Molecular Structure — Plasmodium falciparum/ metabolism | |
| Identifiers | PMID: 1627179 | |
| Full text |
This document has no fulltext available yet, but you can contact its author by using the form below.
|
|
| Citation (ISO format) | NASIR UD, Din et al. Plasmodium falciparum synthesizes O-glycosylated glycoproteins containing O-linked N-acetylglucosamine. In: Biochemistry international, 1992, vol. 27, n° 1, p. 55-64. https://archive-ouverte.unige.ch/unige:10951 |
416 hits 
0 download 
Contact an author
Update