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Scientific article
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Hyperprolactinemia in male NZB/NZW (B/W) F1 mice: accelerated autoimmune disease with normal circulating testosterone

Published inClinical immunology and immunopathology, vol. 71, no. 3, p. 338-343
Publication date1994
Abstract

It has been proposed that the immunostimulatory hormone, prolactin, is associated with flares of systemic lupus erythematosus (SLE). In autoimmune female NZB/NZW F1 (B/W) mice with accelerated lupus-like disease, hyperprolactinemia accelerated autoimmunity. The current study explored effects of moderate and severe hyperprolactinemia in male B/W mice, which have late-onset SLE. Autoimmune disease in B/W males was assessed by measurement of anti-DNA antibodies (anti-DNA), gp70-anti-gp70 immune complexes (gp70IC), IgM, IgG, and renal function. Serum testosterone concentrations were assayed serially. All mice were necropsied when moribund. Hyperprolactinemic B/W males were characterized by premature appearance of anti-DNA and gp70IC and elevation of IgM and IgG. Hyperprolactinemia accelerated mortality with vasculitis and renal disease compared to control mice. Serum testosterone concentrations were not suppressed. In male B/W mice, chronic hyperprolactinemia stimulated autoimmune disease activity; the deleterious effects of prolactin were not mediated through suppression of the immunoprotective hormone, testosterone. This observation supports the proposed association between elevated prolactin levels and exacerbations of SLE.

Keywords
  • Animals
  • Antibodies, Antinuclear/analysis
  • Autoimmune Diseases/etiology
  • Blood Urea Nitrogen
  • Body Weight
  • Disease Models, Animal
  • Female
  • Glycoproteins/blood
  • Hematocrit
  • Hyperprolactinemia/ metabolism
  • Immunoglobulins/blood
  • Leukocyte Count
  • Lupus Erythematosus, Systemic/metabolism
  • Male
  • Mice
  • Prolactin/blood
  • Testosterone/blood
Affiliation Not a UNIGE publication
Citation (ISO format)
MCMURRAY, R. et al. Hyperprolactinemia in male NZB/NZW (B/W) F1 mice: accelerated autoimmune disease with normal circulating testosterone. In: Clinical immunology and immunopathology, 1994, vol. 71, n° 3, p. 338–343. doi: 10.1006/clin.1994.1095
Identifiers
ISSN of the journal0090-1229
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