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Scientific article
English

Relevance of polyclonal antibody formation to the development of autoimmunity : the model of African trypanosomiasis

Published inAdvances in experimental medicine and biology, vol. 114, p. 667-671
Publication date1979
Abstract

There is an induction of anti-DNA antibodies in mice following the administration of bacterial lipopolysaccharides, Dextran sulfate and PPD, which is closely associated with the property of these substances to trigger a polyclonal B cell activation. In the experiments model of African trypanosomiasis there is also an intense polyclonal antibody synthesis paralleled by the formation of several autoantibodies: anti-DNA, anti-bromelain treated mouse red blood cells and antithymocyte antibodies.

Keywords
  • Animals
  • Autoantibodies/ biosynthesis
  • B-Lymphocytes/immunology
  • Clone Cells/immunology
  • DNA/biosynthesis
  • Dextrans/pharmacology
  • Disease Models, Animal
  • Hemolytic Plaque Technique
  • Lipopolysaccharides/pharmacology
  • Mice
  • Mice, Inbred C3H
  • Mice, Nude
  • Poly I-C/pharmacology
  • T-Lymphocytes/immunology
  • Trypanosomiasis, African/ immunology
  • Tuberculin/immunology
Citation (ISO format)
LOUIS, J. A. et al. Relevance of polyclonal antibody formation to the development of autoimmunity : the model of African trypanosomiasis. In: Advances in experimental medicine and biology, 1979, vol. 114, p. 667–671.
Identifiers
  • PID : unige:10937
  • PMID : 380304
ISSN of the journal0065-2598
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