Circulating immune complexes and their possible relevance to other immunological parameters in Guatemalan onchocerciasis

Kawabata, M.; Izui, Shozo; Anan, S.; Kondo, S.; Fukumoto, S.; Flores, G. Z.; Kobayakawa, T.

doi:10.1159/000234854

Scientific article

English

Circulating immune complexes and their possible relevance to other immunological parameters in Guatemalan onchocerciasis

ContributorsKawabata, M.; Izui, Shozo; Anan, S.; Kondo, S.; Fukumoto, S.; Flores, G. Z.; Kobayakawa, T.

Published inInternational archives of allergy and applied immunology, vol. 72, no. 2, p. 128-133

Publication date1983

Abstract

Circulating immune complexes (CIC) were demonstrated in sera of Guatemalan patients with onchocerciasis by Raji cell radioimmunoassay. 44% of patients but none of controls had abnormally high concentrations of CIC in their sera. The increased concentrations of CIC were found more frequently in patients with lower density of microfilariae in their skin biopsies. Patients with higher concentrations of CIC appeared to have increased titers of serum antibodies to Onchocerca volvulus. A depression of both humoral immune response to tetanus toxoid and delayed hypersensitivity reaction to PPD were found in patients with onchocerciasis. CIC may be involved in modulation of the immune response in onchocerciasis.

Keywords

Adolescent
Adult
Aged
Antigen-Antibody Complex/ analysis
Humans
Immunoglobulin A/analysis
Immunoglobulin M/analysis
Microfilaria/isolation & purification
Middle Aged
Onchocerciasis/ immunology
Skin/parasitology
Tetanus Toxoid/immunology
Tuberculin Test

Affiliation Not a UNIGE publication

Citation (ISO format)

KAWABATA, M. et al. Circulating immune complexes and their possible relevance to other immunological parameters in Guatemalan onchocerciasis. In: International archives of allergy and applied immunology, 1983, vol. 72, n° 2, p. 128–133. doi: 10.1159/000234854

Identifiers

PID : unige:10930
DOI : 10.1159/000234854
PMID : 6874107

Commercial URLhttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=234854&Ausgabe=245972&ProduktNr=224161

ISSN of the journal0020-5915

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Circulating immune complexes and their possible relevance to other immunological parameters in Guatemalan onchocerciasis

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