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Title

Gelsolin-actin complex is target for ADP-ribosylation by Clostridium botulinum C2 toxin in intact human neutrophils
Authors
Just, I.
Wille, M.
Chaponnier, Christine
Aktories, K.
Published in European Journal of Pharmacology. 1993, vol. 246, no. 3, p. 293-297
Abstract The gelsolin-actin complex was ADP-ribosylated by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin in lysates of human platelets and human neutrophils. When [32P]orthophosphate-labelled human neutrophils were treated with C. botulinum C2 toxin, [32P]ADP-ribosylated gelsolin-actin was precipitated with anti-gelsolin antibody. Stimulation of neutrophils by formyl-methionine-leucine-phenylalanine decreased the interaction of gelsolin with ADP-ribosylated actin in toxin-treated cells. The data indicate that the gelsolin-actin complex is a pathophysiological substrate for actin-ADP-ribosylating toxins.
Keywords Actins/chemistry/ metabolism — Adenosine Diphosphate Ribose/ metabolism — Blood Platelets/drug effects/metabolism — Botulinum Toxins/ pharmacology — Gelsolin/chemistry/ metabolism — Humans — Neutrophils/ drug effects/metabolism
Identifiers
PMID: 8223953
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(ISO format) 		JUST, I. et al. Gelsolin-actin complex is target for ADP-ribosylation by Clostridium botulinum C2 toxin in intact human neutrophils. In: European Journal of Pharmacology, 1993, vol. 246, n° 3, p. 293-297. https://archive-ouverte.unige.ch/unige:10928

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Deposited on : 2010-08-26

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